Synthesis of Quinazolin-4-ones by Copper-Catalyzed Isocyanide Insertion

[Image: see text] Herein, we report a novel copper-catalyzed imidoylative cross-coupling/cyclocondensation reaction between 2-isocyanobenzoates and amines efficiently producing quinazolin-4-ones. The reaction utilizes Cu(II) acetate as an environmentally benign catalyst in combination with a mild ba...

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Detalles Bibliográficos
Autores principales: Collet, Jurriën W., van der Nol, Edith A., Roose, Tom R., Maes, Bert U. W., Ruijter, Eelco, Orru, Romano V. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281788/
https://www.ncbi.nlm.nih.gov/pubmed/32400159
http://dx.doi.org/10.1021/acs.joc.0c00771

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