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The Association between Leukocyte and Its Subtypes and Benign Breast Disease: The TCLSIH Cohort Study

Inflammation plays a crucial role in the formation of benign breast disease. Given the limited study to explore the association between leukocyte as an indicator of immune system and benign breast disease, we used data from a large cross-sectional study to investigate association between leukocyte a...

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Autores principales: Song, Yanqi, Wang, Xuena, Huang, Liyan, Gu, Yeqing, Cao, Xingqi, Fu, Jingzhu, Wu, Hongmei, Li, Xiaojiang, Kong, Fanming, Sun, Binxu, Sun, Ruitian, Zhang, Qing, Liu, Li, Meng, Ge, Zhang, Shunming, Jia, Yingjie, Niu, Kaijun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281813/
https://www.ncbi.nlm.nih.gov/pubmed/32565800
http://dx.doi.org/10.1155/2020/3560593
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author Song, Yanqi
Wang, Xuena
Huang, Liyan
Gu, Yeqing
Cao, Xingqi
Fu, Jingzhu
Wu, Hongmei
Li, Xiaojiang
Kong, Fanming
Sun, Binxu
Sun, Ruitian
Zhang, Qing
Liu, Li
Meng, Ge
Zhang, Shunming
Jia, Yingjie
Niu, Kaijun
author_facet Song, Yanqi
Wang, Xuena
Huang, Liyan
Gu, Yeqing
Cao, Xingqi
Fu, Jingzhu
Wu, Hongmei
Li, Xiaojiang
Kong, Fanming
Sun, Binxu
Sun, Ruitian
Zhang, Qing
Liu, Li
Meng, Ge
Zhang, Shunming
Jia, Yingjie
Niu, Kaijun
author_sort Song, Yanqi
collection PubMed
description Inflammation plays a crucial role in the formation of benign breast disease. Given the limited study to explore the association between leukocyte as an indicator of immune system and benign breast disease, we used data from a large cross-sectional study to investigate association between leukocyte and its subtypes and benign breast disease among women in the general population. The data were derived from baseline data of the Tianjin chronic low-grade systemic inflammation and health (TCLSIH) cohort study during 2014 and 2016. Breast thickness and nodules status were assessed by using ultrasonography. Leukocyte and its subtype counts were carried out using the automated hematology analyzer. Multiple logistic regression analysis was used to examine the association between leukocyte and its subtypes and prevalence of benign breast disease. In the present study, the prevalence of benign breast disease was 20.9%. After adjustments for potentially confounding factors, the odds ratios (95% confidence interval) for benign breast disease across lymphocyte quintiles were as follows: 1.00 (reference), 0.99 (0.82, 1.2), 0.85 (0.69, 1.04), 0.84 (0.68, 1.02), and 0.75 (0.61, 0.92) (P for trend = 0.002). An inverse association between lymphocyte counts and benign breast disease was found, but leukocyte and other subtypes have nothing to do with benign breast disease. Further prospective studies are needed to determine the findings.
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spelling pubmed-72818132020-06-19 The Association between Leukocyte and Its Subtypes and Benign Breast Disease: The TCLSIH Cohort Study Song, Yanqi Wang, Xuena Huang, Liyan Gu, Yeqing Cao, Xingqi Fu, Jingzhu Wu, Hongmei Li, Xiaojiang Kong, Fanming Sun, Binxu Sun, Ruitian Zhang, Qing Liu, Li Meng, Ge Zhang, Shunming Jia, Yingjie Niu, Kaijun J Oncol Research Article Inflammation plays a crucial role in the formation of benign breast disease. Given the limited study to explore the association between leukocyte as an indicator of immune system and benign breast disease, we used data from a large cross-sectional study to investigate association between leukocyte and its subtypes and benign breast disease among women in the general population. The data were derived from baseline data of the Tianjin chronic low-grade systemic inflammation and health (TCLSIH) cohort study during 2014 and 2016. Breast thickness and nodules status were assessed by using ultrasonography. Leukocyte and its subtype counts were carried out using the automated hematology analyzer. Multiple logistic regression analysis was used to examine the association between leukocyte and its subtypes and prevalence of benign breast disease. In the present study, the prevalence of benign breast disease was 20.9%. After adjustments for potentially confounding factors, the odds ratios (95% confidence interval) for benign breast disease across lymphocyte quintiles were as follows: 1.00 (reference), 0.99 (0.82, 1.2), 0.85 (0.69, 1.04), 0.84 (0.68, 1.02), and 0.75 (0.61, 0.92) (P for trend = 0.002). An inverse association between lymphocyte counts and benign breast disease was found, but leukocyte and other subtypes have nothing to do with benign breast disease. Further prospective studies are needed to determine the findings. Hindawi 2020-05-31 /pmc/articles/PMC7281813/ /pubmed/32565800 http://dx.doi.org/10.1155/2020/3560593 Text en Copyright © 2020 Yanqi Song et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Song, Yanqi
Wang, Xuena
Huang, Liyan
Gu, Yeqing
Cao, Xingqi
Fu, Jingzhu
Wu, Hongmei
Li, Xiaojiang
Kong, Fanming
Sun, Binxu
Sun, Ruitian
Zhang, Qing
Liu, Li
Meng, Ge
Zhang, Shunming
Jia, Yingjie
Niu, Kaijun
The Association between Leukocyte and Its Subtypes and Benign Breast Disease: The TCLSIH Cohort Study
title The Association between Leukocyte and Its Subtypes and Benign Breast Disease: The TCLSIH Cohort Study
title_full The Association between Leukocyte and Its Subtypes and Benign Breast Disease: The TCLSIH Cohort Study
title_fullStr The Association between Leukocyte and Its Subtypes and Benign Breast Disease: The TCLSIH Cohort Study
title_full_unstemmed The Association between Leukocyte and Its Subtypes and Benign Breast Disease: The TCLSIH Cohort Study
title_short The Association between Leukocyte and Its Subtypes and Benign Breast Disease: The TCLSIH Cohort Study
title_sort association between leukocyte and its subtypes and benign breast disease: the tclsih cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281813/
https://www.ncbi.nlm.nih.gov/pubmed/32565800
http://dx.doi.org/10.1155/2020/3560593
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