The replication machinery of LUCA: common origin of DNA replication and transcription

Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsib...

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Autores principales: Koonin, Eugene V., Krupovic, Mart, Ishino, Sonoko, Ishino, Yoshizumi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Opinion
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281927/
https://www.ncbi.nlm.nih.gov/pubmed/32517760
http://dx.doi.org/10.1186/s12915-020-00800-9
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author Koonin, Eugene V.
Krupovic, Mart
Ishino, Sonoko
Ishino, Yoshizumi
author_facet Koonin, Eugene V.
Krupovic, Mart
Ishino, Sonoko
Ishino, Yoshizumi
author_sort Koonin, Eugene V.
collection PubMed
description Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcription suggests a parsimonious evolutionary scenario. Under this model, RNAPs and replicative DNAPs evolved from a common ancestor that functioned as an RNA-dependent RNA polymerase in the RNA-protein world that predated the advent of DNA replication. The replicative DNAP of the Last Universal Cellular Ancestor (LUCA) would be the ancestor of the archaeal PolD.
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spelling pubmed-72819272020-06-09 The replication machinery of LUCA: common origin of DNA replication and transcription Koonin, Eugene V. Krupovic, Mart Ishino, Sonoko Ishino, Yoshizumi BMC Biol Opinion Origin of DNA replication is an enigma because the replicative DNA polymerases (DNAPs) are not homologous among the three domains of life, Bacteria, Archaea, and Eukarya. The homology between the archaeal replicative DNAP (PolD) and the large subunits of the universal RNA polymerase (RNAP) responsible for transcription suggests a parsimonious evolutionary scenario. Under this model, RNAPs and replicative DNAPs evolved from a common ancestor that functioned as an RNA-dependent RNA polymerase in the RNA-protein world that predated the advent of DNA replication. The replicative DNAP of the Last Universal Cellular Ancestor (LUCA) would be the ancestor of the archaeal PolD. BioMed Central 2020-06-09 /pmc/articles/PMC7281927/ /pubmed/32517760 http://dx.doi.org/10.1186/s12915-020-00800-9 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Opinion
Koonin, Eugene V.
Krupovic, Mart
Ishino, Sonoko
Ishino, Yoshizumi
The replication machinery of LUCA: common origin of DNA replication and transcription
title The replication machinery of LUCA: common origin of DNA replication and transcription
title_full The replication machinery of LUCA: common origin of DNA replication and transcription
title_fullStr The replication machinery of LUCA: common origin of DNA replication and transcription
title_full_unstemmed The replication machinery of LUCA: common origin of DNA replication and transcription
title_short The replication machinery of LUCA: common origin of DNA replication and transcription
title_sort replication machinery of luca: common origin of dna replication and transcription
topic Opinion
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7281927/
https://www.ncbi.nlm.nih.gov/pubmed/32517760
http://dx.doi.org/10.1186/s12915-020-00800-9
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