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The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study

Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body compos...

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Autores principales: Gigic, Biljana, Nattenmüller, Johanna, Schneider, Martin, Kulu, Yakup, Syrjala, Karen L., Böhm, Jürgen, Schrotz-King, Petra, Brenner, Hermann, Colditz, Graham A., Figueiredo, Jane C., Grady, William M., Li, Christopher I., Shibata, David, Siegel, Erin M., Toriola, Adetunji T., Kauczor, Hans-Ulrich, Ulrich, Alexis, Ulrich, Cornelia M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282010/
https://www.ncbi.nlm.nih.gov/pubmed/32353960
http://dx.doi.org/10.3390/nu12051247
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author Gigic, Biljana
Nattenmüller, Johanna
Schneider, Martin
Kulu, Yakup
Syrjala, Karen L.
Böhm, Jürgen
Schrotz-King, Petra
Brenner, Hermann
Colditz, Graham A.
Figueiredo, Jane C.
Grady, William M.
Li, Christopher I.
Shibata, David
Siegel, Erin M.
Toriola, Adetunji T.
Kauczor, Hans-Ulrich
Ulrich, Alexis
Ulrich, Cornelia M.
author_facet Gigic, Biljana
Nattenmüller, Johanna
Schneider, Martin
Kulu, Yakup
Syrjala, Karen L.
Böhm, Jürgen
Schrotz-King, Petra
Brenner, Hermann
Colditz, Graham A.
Figueiredo, Jane C.
Grady, William M.
Li, Christopher I.
Shibata, David
Siegel, Erin M.
Toriola, Adetunji T.
Kauczor, Hans-Ulrich
Ulrich, Alexis
Ulrich, Cornelia M.
author_sort Gigic, Biljana
collection PubMed
description Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients. Methods: A total of 138 newly diagnosed CRC patients underwent CT scans at diagnosis and completed questionnaires prior to and six and twelve months post-surgery. We investigated the associations of VFA, SFA, and SMM with HRQoL at multiple time points. Results: A higher VFA was associated with increased pain six and twelve months post-surgery (β = 0.06, p = 0.04 and β = 0.07, p = 0.01) and with worse social functioning six months post-surgery (β = −0.08, p = 0.01). Higher SMM was associated with increased pain twelve months post-surgery (β = 1.03, p < 0.01). Conclusions: CT-quantified body composition is associated with HRQoL scales post-surgery. Intervention strategies targeting a reduction in VFA and maintaining SMM might improve HRQoL in CRC patients during the first year post-surgery.
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spelling pubmed-72820102020-06-19 The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study Gigic, Biljana Nattenmüller, Johanna Schneider, Martin Kulu, Yakup Syrjala, Karen L. Böhm, Jürgen Schrotz-King, Petra Brenner, Hermann Colditz, Graham A. Figueiredo, Jane C. Grady, William M. Li, Christopher I. Shibata, David Siegel, Erin M. Toriola, Adetunji T. Kauczor, Hans-Ulrich Ulrich, Alexis Ulrich, Cornelia M. Nutrients Article Background: Obesity, defined by body mass index (BMI), measured at colorectal cancer (CRC) diagnosis has been associated with postoperative complications and survival outcomes. However, BMI does not allow for a differentiation between fat and muscle mass. Computed tomography (CT)-defined body composition more accurately reflects different types of tissue and their associations with health-related quality of life (HRQoL) during the first year of disease, but this has not been investigated yet. We studied the role of visceral and subcutaneous fat area (VFA and SFA) and skeletal muscle mass (SMM) on longitudinally assessed HRQoL in CRC patients. Methods: A total of 138 newly diagnosed CRC patients underwent CT scans at diagnosis and completed questionnaires prior to and six and twelve months post-surgery. We investigated the associations of VFA, SFA, and SMM with HRQoL at multiple time points. Results: A higher VFA was associated with increased pain six and twelve months post-surgery (β = 0.06, p = 0.04 and β = 0.07, p = 0.01) and with worse social functioning six months post-surgery (β = −0.08, p = 0.01). Higher SMM was associated with increased pain twelve months post-surgery (β = 1.03, p < 0.01). Conclusions: CT-quantified body composition is associated with HRQoL scales post-surgery. Intervention strategies targeting a reduction in VFA and maintaining SMM might improve HRQoL in CRC patients during the first year post-surgery. MDPI 2020-04-28 /pmc/articles/PMC7282010/ /pubmed/32353960 http://dx.doi.org/10.3390/nu12051247 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Gigic, Biljana
Nattenmüller, Johanna
Schneider, Martin
Kulu, Yakup
Syrjala, Karen L.
Böhm, Jürgen
Schrotz-King, Petra
Brenner, Hermann
Colditz, Graham A.
Figueiredo, Jane C.
Grady, William M.
Li, Christopher I.
Shibata, David
Siegel, Erin M.
Toriola, Adetunji T.
Kauczor, Hans-Ulrich
Ulrich, Alexis
Ulrich, Cornelia M.
The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study
title The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study
title_full The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study
title_fullStr The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study
title_full_unstemmed The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study
title_short The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study
title_sort role of ct-quantified body composition on longitudinal health-related quality of life in colorectal cancer patients: the colocare study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282010/
https://www.ncbi.nlm.nih.gov/pubmed/32353960
http://dx.doi.org/10.3390/nu12051247
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