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R269C variant of ESR1: high prevalence and differential function in a subset of pancreatic cancers

BACKGROUND: Estrogen receptor α (ESR1) plays a critical role in promoting growth of various cancers. Yet, its role in the development of pancreatic cancer is not well-defined. A less studied region of ESR1 is the hinge region, connecting the ligand binding and DNA domains. rs142712646 is a rare SNP...

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Detalles Bibliográficos
Autores principales:	Boldes, Tomer, Merenbakh-Lamin, Keren, Journo, Shani, Shachar, Eliya, Lipson, Doron, Yeheskel, Adva, Pasmanik-Chor, Metsada, Rubinek, Tami, Wolf, Ido
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282172/ https://www.ncbi.nlm.nih.gov/pubmed/32513126 http://dx.doi.org/10.1186/s12885-020-07005-x

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