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Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis

Lipid metabolism is an important and complex biochemical process involved in the storage of energy and maintenance of normal biological functions. Leucine, a branched amino acid, has anti-obesity effects on glucose tolerance, lipid metabolism, and insulin sensitivity. Leucine also modulates mitochon...

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Autores principales: Zhang, Lingyu, Li, Fengna, Guo, Qiuping, Duan, Yehui, Wang, Wenlong, Zhong, Yinzhao, Yang, Yuhuan, Yin, Yulong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282259/
https://www.ncbi.nlm.nih.gov/pubmed/32370170
http://dx.doi.org/10.3390/nu12051299
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author Zhang, Lingyu
Li, Fengna
Guo, Qiuping
Duan, Yehui
Wang, Wenlong
Zhong, Yinzhao
Yang, Yuhuan
Yin, Yulong
author_facet Zhang, Lingyu
Li, Fengna
Guo, Qiuping
Duan, Yehui
Wang, Wenlong
Zhong, Yinzhao
Yang, Yuhuan
Yin, Yulong
author_sort Zhang, Lingyu
collection PubMed
description Lipid metabolism is an important and complex biochemical process involved in the storage of energy and maintenance of normal biological functions. Leucine, a branched amino acid, has anti-obesity effects on glucose tolerance, lipid metabolism, and insulin sensitivity. Leucine also modulates mitochondrial dysfunction, representing a new strategy to target aging, neurodegenerative disease, obesity, diabetes, and cardiovascular disease. Although various studies have been carried out, much uncertainty still exists and further studies are required to fully elucidate the relationship between leucine and lipid metabolism. This review offers an up-to-date report on leucine, as key roles in both lipid metabolism and energy homeostasis in vivo and in vitro by acceleration of fatty acid oxidation, lipolysis, activation of the adenosine 5′-monophosphate-activated protein kinase (AMPK)–silent information regulator of transcription 1 (SIRT1)–proliferator-activated receptor γ coactivator-1α (PGC-1α) pathway, synthesis, and/or secretion of adipokines and stability of the gut microbiota.
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spelling pubmed-72822592020-06-19 Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis Zhang, Lingyu Li, Fengna Guo, Qiuping Duan, Yehui Wang, Wenlong Zhong, Yinzhao Yang, Yuhuan Yin, Yulong Nutrients Review Lipid metabolism is an important and complex biochemical process involved in the storage of energy and maintenance of normal biological functions. Leucine, a branched amino acid, has anti-obesity effects on glucose tolerance, lipid metabolism, and insulin sensitivity. Leucine also modulates mitochondrial dysfunction, representing a new strategy to target aging, neurodegenerative disease, obesity, diabetes, and cardiovascular disease. Although various studies have been carried out, much uncertainty still exists and further studies are required to fully elucidate the relationship between leucine and lipid metabolism. This review offers an up-to-date report on leucine, as key roles in both lipid metabolism and energy homeostasis in vivo and in vitro by acceleration of fatty acid oxidation, lipolysis, activation of the adenosine 5′-monophosphate-activated protein kinase (AMPK)–silent information regulator of transcription 1 (SIRT1)–proliferator-activated receptor γ coactivator-1α (PGC-1α) pathway, synthesis, and/or secretion of adipokines and stability of the gut microbiota. MDPI 2020-05-02 /pmc/articles/PMC7282259/ /pubmed/32370170 http://dx.doi.org/10.3390/nu12051299 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhang, Lingyu
Li, Fengna
Guo, Qiuping
Duan, Yehui
Wang, Wenlong
Zhong, Yinzhao
Yang, Yuhuan
Yin, Yulong
Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis
title Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis
title_full Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis
title_fullStr Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis
title_full_unstemmed Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis
title_short Leucine Supplementation: A Novel Strategy for Modulating Lipid Metabolism and Energy Homeostasis
title_sort leucine supplementation: a novel strategy for modulating lipid metabolism and energy homeostasis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282259/
https://www.ncbi.nlm.nih.gov/pubmed/32370170
http://dx.doi.org/10.3390/nu12051299
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