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Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise

Intensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive effects on exercise-induced oxidative stress. Nevertheless, it remains uncertain whether...

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Autores principales: Ruiz-Iglesias, Patricia, Estruel-Amades, Sheila, Camps-Bossacoma, Mariona, Massot-Cladera, Malén, Franch, Àngels, Pérez-Cano, Francisco J., Castell, Margarida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282260/
https://www.ncbi.nlm.nih.gov/pubmed/32369998
http://dx.doi.org/10.3390/nu12051291
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author Ruiz-Iglesias, Patricia
Estruel-Amades, Sheila
Camps-Bossacoma, Mariona
Massot-Cladera, Malén
Franch, Àngels
Pérez-Cano, Francisco J.
Castell, Margarida
author_facet Ruiz-Iglesias, Patricia
Estruel-Amades, Sheila
Camps-Bossacoma, Mariona
Massot-Cladera, Malén
Franch, Àngels
Pérez-Cano, Francisco J.
Castell, Margarida
author_sort Ruiz-Iglesias, Patricia
collection PubMed
description Intensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive effects on exercise-induced oxidative stress. Nevertheless, it remains uncertain whether it also prevents exhausting exercise-induced immune alterations. The aim of this study was to establish the effect of oral hesperidin supplementation on the systemic immune system in rats following an intensive training and exhausting exercise. For this purpose, female Wistar rats were randomized into an intensive training group or a sedentary group. Intensive training was induced by running in a treadmill 5 days per week (including two exhausting tests) for five weeks. Throughout the training period, 200 mg/kg of hesperidin or vehicle was administered by oral gavage three times per week. At the end, blood, thymus, spleen and macrophages were collected before, immediately after and 24 h after an additional final exhaustion test. Hesperidin supplementation enhanced natural killer cell cytotoxicity and the proportion of phagocytic monocytes, attenuated the secretion of cytokines by stimulated macrophages, prevented the leukocytosis induced by exhaustion and increased the proportion of T helper cells in the thymus, blood and spleen. These results suggest that hesperidin can prevent exhausting exercise-induced immune alterations.
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spelling pubmed-72822602020-06-19 Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise Ruiz-Iglesias, Patricia Estruel-Amades, Sheila Camps-Bossacoma, Mariona Massot-Cladera, Malén Franch, Àngels Pérez-Cano, Francisco J. Castell, Margarida Nutrients Article Intensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive effects on exercise-induced oxidative stress. Nevertheless, it remains uncertain whether it also prevents exhausting exercise-induced immune alterations. The aim of this study was to establish the effect of oral hesperidin supplementation on the systemic immune system in rats following an intensive training and exhausting exercise. For this purpose, female Wistar rats were randomized into an intensive training group or a sedentary group. Intensive training was induced by running in a treadmill 5 days per week (including two exhausting tests) for five weeks. Throughout the training period, 200 mg/kg of hesperidin or vehicle was administered by oral gavage three times per week. At the end, blood, thymus, spleen and macrophages were collected before, immediately after and 24 h after an additional final exhaustion test. Hesperidin supplementation enhanced natural killer cell cytotoxicity and the proportion of phagocytic monocytes, attenuated the secretion of cytokines by stimulated macrophages, prevented the leukocytosis induced by exhaustion and increased the proportion of T helper cells in the thymus, blood and spleen. These results suggest that hesperidin can prevent exhausting exercise-induced immune alterations. MDPI 2020-05-01 /pmc/articles/PMC7282260/ /pubmed/32369998 http://dx.doi.org/10.3390/nu12051291 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ruiz-Iglesias, Patricia
Estruel-Amades, Sheila
Camps-Bossacoma, Mariona
Massot-Cladera, Malén
Franch, Àngels
Pérez-Cano, Francisco J.
Castell, Margarida
Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise
title Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise
title_full Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise
title_fullStr Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise
title_full_unstemmed Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise
title_short Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise
title_sort influence of hesperidin on systemic immunity of rats following an intensive training and exhausting exercise
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282260/
https://www.ncbi.nlm.nih.gov/pubmed/32369998
http://dx.doi.org/10.3390/nu12051291
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