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Point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy

INTRODUCTION: Urinary tract infections (UTIs) are the second most common type of infection worldwide, accounting for a large number of primary care consultations and antibiotic prescribing. Current diagnosis is based on an empirical approach, relying on symptoms and occasional use of urine dipsticks...

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Autores principales: Fraile Navarro, David, Sullivan, Frank, Azcoaga-Lorenzo, Amaya, Hernandez Santiago, Virginia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282288/
https://www.ncbi.nlm.nih.gov/pubmed/32499256
http://dx.doi.org/10.1136/bmjopen-2019-033424
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author Fraile Navarro, David
Sullivan, Frank
Azcoaga-Lorenzo, Amaya
Hernandez Santiago, Virginia
author_facet Fraile Navarro, David
Sullivan, Frank
Azcoaga-Lorenzo, Amaya
Hernandez Santiago, Virginia
author_sort Fraile Navarro, David
collection PubMed
description INTRODUCTION: Urinary tract infections (UTIs) are the second most common type of infection worldwide, accounting for a large number of primary care consultations and antibiotic prescribing. Current diagnosis is based on an empirical approach, relying on symptoms and occasional use of urine dipsticks. The diagnostic reference standard is still urine culture, although it is not routinely recommended for uncomplicated UTIs in the community, due to time to diagnosis (48 hours). Faster point-of-care tests have been developed, but their diagnostic accuracy has not been compared. Our objective is to systematically review and meta-analyse the diagnostic accuracy of currently available point-of-care tests for UTIs. METHODS AND ANALYSIS: Studies evaluating the diagnostic accuracy of point-of-care tests for UTIs will be included. PubMed, Web of Science, Embase and Cochrane Database of Systematic Reviews were searched from inception to 1 June 2019. Data extraction and risk-of-bias assessment will be assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. Meta-analysis will be performed depending on data availability and heterogeneity. ETHICS AND DISSEMINATION: This is a systematic review protocol and therefore formal ethical approval is not required, as no primary, identifiable, personal data will be collected. Patients or the public were not involved in the design of our research. However, the findings from this review will be shared with key stakeholders, including patient groups, clinicians and guideline developers, and will also be presented and national and international conferences. PROSPERO REGISTRATION NUMBER: CRD42018112019.
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spelling pubmed-72822882020-06-15 Point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy Fraile Navarro, David Sullivan, Frank Azcoaga-Lorenzo, Amaya Hernandez Santiago, Virginia BMJ Open General practice / Family practice INTRODUCTION: Urinary tract infections (UTIs) are the second most common type of infection worldwide, accounting for a large number of primary care consultations and antibiotic prescribing. Current diagnosis is based on an empirical approach, relying on symptoms and occasional use of urine dipsticks. The diagnostic reference standard is still urine culture, although it is not routinely recommended for uncomplicated UTIs in the community, due to time to diagnosis (48 hours). Faster point-of-care tests have been developed, but their diagnostic accuracy has not been compared. Our objective is to systematically review and meta-analyse the diagnostic accuracy of currently available point-of-care tests for UTIs. METHODS AND ANALYSIS: Studies evaluating the diagnostic accuracy of point-of-care tests for UTIs will be included. PubMed, Web of Science, Embase and Cochrane Database of Systematic Reviews were searched from inception to 1 June 2019. Data extraction and risk-of-bias assessment will be assessed using the Quality Assessment of Diagnostic Accuracy Studies tool. Meta-analysis will be performed depending on data availability and heterogeneity. ETHICS AND DISSEMINATION: This is a systematic review protocol and therefore formal ethical approval is not required, as no primary, identifiable, personal data will be collected. Patients or the public were not involved in the design of our research. However, the findings from this review will be shared with key stakeholders, including patient groups, clinicians and guideline developers, and will also be presented and national and international conferences. PROSPERO REGISTRATION NUMBER: CRD42018112019. BMJ Publishing Group 2020-06-03 /pmc/articles/PMC7282288/ /pubmed/32499256 http://dx.doi.org/10.1136/bmjopen-2019-033424 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.
spellingShingle General practice / Family practice
Fraile Navarro, David
Sullivan, Frank
Azcoaga-Lorenzo, Amaya
Hernandez Santiago, Virginia
Point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy
title Point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy
title_full Point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy
title_fullStr Point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy
title_full_unstemmed Point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy
title_short Point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy
title_sort point-of-care tests for urinary tract infections: protocol for a systematic review and meta-analysis of diagnostic test accuracy
topic General practice / Family practice
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282288/
https://www.ncbi.nlm.nih.gov/pubmed/32499256
http://dx.doi.org/10.1136/bmjopen-2019-033424
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