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Hirudin Reduces the Expression of Markers of the Extracellular Matrix in Renal Tubular Epithelial Cells in a Rat Model of Diabetic Kidney Disease Through the Hypoxia-Inducible Factor-1α (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway

BACKGROUND: This study aimed to investigate the effects of hirudin on the production of extracellular matrix (ECM) factors by renal tubular epithelial cells in a rat model of diabetic kidney disease (DKD) and HK-2 human renal tubule epithelial cells. MATERIAL/METHODS: Sprague-Dawley rats were divide...

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Detalles Bibliográficos
Autores principales:	Pang, Xinxin, Zhang, Yage, Shi, Xiujie, Peng, Zining, Xing, Yufeng, Han, Jiarui
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	International Scientific Literature, Inc. 2020
Materias:	Lab/In Vitro Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282348/ https://www.ncbi.nlm.nih.gov/pubmed/32473006 http://dx.doi.org/10.12659/MSM.921894

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