Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein

BACKGROUND: Natural killer and cytotoxic CD8(+) T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor elimination through recognition of the MHC class I chain-related proteins A and B (MICA and MICB). Both molecules are overexpressed on a...

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Detalles Bibliográficos
Autores principales: Torres, Nicolas, Regge, María Victoria, Secchiari, Florencia, Friedrich, Adrián David, Spallanzani, Raúl Germán, Raffo Iraolagoitia, Ximena Lucía, Núñez, Sol Yanel, Sierra, Jessica Mariel, Ziblat, Andrea, Santilli, María Cecilia, Gilio, Nicolás, Almada, Evangelina, Lauche, Constanza, Pardo, Romina, Domaica, Carolina Inés, Fuertes, Mercedes Beatriz, Madauss, Kevin Patrick, Hance, Kenneth W, Gloger, Israel S, Zylberman, Vanesa, Goldbaum, Fernando Alberto, Zwirner, Norberto Walter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282397/
https://www.ncbi.nlm.nih.gov/pubmed/32518090
http://dx.doi.org/10.1136/jitc-2019-000233

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