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INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study

OBJECTIVES: To describe the construction of the international INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) standards for child development at 2 years by reporting the cognitive, language, motor and behaviour outcomes in optimally healthy and nourished children in the INTERGROWTH-21st Pro...

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Autores principales: Fernandes, Michelle, Villar, José, Stein, Alan, Staines Urias, Eleonora, Garza, Cutberto, Victora, Cesar G, Barros, Fernando C, Bertino, Enrico, Purwar, Manorama, Carvalho, Maria, Giuliani, Francesca, Wulff, Katharina, Abubakar, Amina A, Kihara, Michael, Cheikh Ismail, Leila, Aranzeta, Luis, Albernaz, Elaine, Kunnawar, Naina, Di Nicola, Paola, Ochieng, Roseline, Sandells, Tamsin, Savini, Sandy, Temple, Sophie, Murray, Elizabeth, Ohuma, Eric O, Gravett, Michael G, Pang, Ruyan, Jaffer, Yasmine A, Noble, Julia Alison, Winsey, Adele, Lambert, Ann, Papageorghiou, Aris T, Bhutta, Zulfiqar, Kennedy, Stephen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282399/
https://www.ncbi.nlm.nih.gov/pubmed/32513882
http://dx.doi.org/10.1136/bmjopen-2019-035258
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author Fernandes, Michelle
Villar, José
Stein, Alan
Staines Urias, Eleonora
Garza, Cutberto
Victora, Cesar G
Barros, Fernando C
Bertino, Enrico
Purwar, Manorama
Carvalho, Maria
Giuliani, Francesca
Wulff, Katharina
Abubakar, Amina A
Kihara, Michael
Cheikh Ismail, Leila
Aranzeta, Luis
Albernaz, Elaine
Kunnawar, Naina
Di Nicola, Paola
Ochieng, Roseline
Sandells, Tamsin
Savini, Sandy
Temple, Sophie
Murray, Elizabeth
Ohuma, Eric O
Gravett, Michael G
Pang, Ruyan
Jaffer, Yasmine A
Noble, Julia Alison
Winsey, Adele
Lambert, Ann
Papageorghiou, Aris T
Bhutta, Zulfiqar
Kennedy, Stephen
author_facet Fernandes, Michelle
Villar, José
Stein, Alan
Staines Urias, Eleonora
Garza, Cutberto
Victora, Cesar G
Barros, Fernando C
Bertino, Enrico
Purwar, Manorama
Carvalho, Maria
Giuliani, Francesca
Wulff, Katharina
Abubakar, Amina A
Kihara, Michael
Cheikh Ismail, Leila
Aranzeta, Luis
Albernaz, Elaine
Kunnawar, Naina
Di Nicola, Paola
Ochieng, Roseline
Sandells, Tamsin
Savini, Sandy
Temple, Sophie
Murray, Elizabeth
Ohuma, Eric O
Gravett, Michael G
Pang, Ruyan
Jaffer, Yasmine A
Noble, Julia Alison
Winsey, Adele
Lambert, Ann
Papageorghiou, Aris T
Bhutta, Zulfiqar
Kennedy, Stephen
author_sort Fernandes, Michelle
collection PubMed
description OBJECTIVES: To describe the construction of the international INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) standards for child development at 2 years by reporting the cognitive, language, motor and behaviour outcomes in optimally healthy and nourished children in the INTERGROWTH-21st Project. DESIGN: Population-based cohort study, the INTERGROWTH-21st Project. SETTING: Brazil, India, Italy, Kenya and the UK. PARTICIPANTS: 1181 children prospectively recruited from early fetal life according to the prescriptive WHO approach, and confirmed to be at low risk of adverse perinatal and postnatal outcomes. PRIMARY MEASURES: Scaled INTER-NDA domain scores for cognition, language, fine and gross motor skills and behaviour; vision outcomes measured on the Cardiff tests; attentional problems and emotional reactivity measured on the respective subscales of the preschool Child Behaviour Checklist; and the age of acquisition of the WHO gross motor milestones. RESULTS: Scaled INTER-NDA domain scores are presented as centiles, which were constructed according to the prescriptive WHO approach and excluded children born preterm and those with significant postnatal/neurological morbidity. For all domains, except negative behaviour, higher scores reflect better outcomes and the threshold for normality was defined as ≥10th centile. For the INTER-NDA’s cognitive, fine motor, gross motor, language and positive behaviour domains these are ≥38.5, ≥25.7, ≥51.7, ≥17.8 and ≥51.4, respectively. The threshold for normality for the INTER-NDA’s negative behaviour domain is ≤50.0, that is, ≤90th centile. At 22–30 months of age, the cohort overlapped with the WHO motor milestone centiles, showed low postnatal morbidity (<10%), and vision outcomes, attentional problems and emotional reactivity scores within the respective normative ranges. CONCLUSIONS: From this large, healthy and well-nourished, international cohort, we have constructed, using the WHO prescriptive methodology, international INTER-NDA standards for child development at 2 years of age. Standards, rather than references, are recommended for population-level screening and the identification of children at risk of adverse outcomes.
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spelling pubmed-72823992020-06-15 INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study Fernandes, Michelle Villar, José Stein, Alan Staines Urias, Eleonora Garza, Cutberto Victora, Cesar G Barros, Fernando C Bertino, Enrico Purwar, Manorama Carvalho, Maria Giuliani, Francesca Wulff, Katharina Abubakar, Amina A Kihara, Michael Cheikh Ismail, Leila Aranzeta, Luis Albernaz, Elaine Kunnawar, Naina Di Nicola, Paola Ochieng, Roseline Sandells, Tamsin Savini, Sandy Temple, Sophie Murray, Elizabeth Ohuma, Eric O Gravett, Michael G Pang, Ruyan Jaffer, Yasmine A Noble, Julia Alison Winsey, Adele Lambert, Ann Papageorghiou, Aris T Bhutta, Zulfiqar Kennedy, Stephen BMJ Open Paediatrics OBJECTIVES: To describe the construction of the international INTERGROWTH-21st Neurodevelopment Assessment (INTER-NDA) standards for child development at 2 years by reporting the cognitive, language, motor and behaviour outcomes in optimally healthy and nourished children in the INTERGROWTH-21st Project. DESIGN: Population-based cohort study, the INTERGROWTH-21st Project. SETTING: Brazil, India, Italy, Kenya and the UK. PARTICIPANTS: 1181 children prospectively recruited from early fetal life according to the prescriptive WHO approach, and confirmed to be at low risk of adverse perinatal and postnatal outcomes. PRIMARY MEASURES: Scaled INTER-NDA domain scores for cognition, language, fine and gross motor skills and behaviour; vision outcomes measured on the Cardiff tests; attentional problems and emotional reactivity measured on the respective subscales of the preschool Child Behaviour Checklist; and the age of acquisition of the WHO gross motor milestones. RESULTS: Scaled INTER-NDA domain scores are presented as centiles, which were constructed according to the prescriptive WHO approach and excluded children born preterm and those with significant postnatal/neurological morbidity. For all domains, except negative behaviour, higher scores reflect better outcomes and the threshold for normality was defined as ≥10th centile. For the INTER-NDA’s cognitive, fine motor, gross motor, language and positive behaviour domains these are ≥38.5, ≥25.7, ≥51.7, ≥17.8 and ≥51.4, respectively. The threshold for normality for the INTER-NDA’s negative behaviour domain is ≤50.0, that is, ≤90th centile. At 22–30 months of age, the cohort overlapped with the WHO motor milestone centiles, showed low postnatal morbidity (<10%), and vision outcomes, attentional problems and emotional reactivity scores within the respective normative ranges. CONCLUSIONS: From this large, healthy and well-nourished, international cohort, we have constructed, using the WHO prescriptive methodology, international INTER-NDA standards for child development at 2 years of age. Standards, rather than references, are recommended for population-level screening and the identification of children at risk of adverse outcomes. BMJ Publishing Group 2020-06-07 /pmc/articles/PMC7282399/ /pubmed/32513882 http://dx.doi.org/10.1136/bmjopen-2019-035258 Text en © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See: https://creativecommons.org/licenses/by/4.0/.
spellingShingle Paediatrics
Fernandes, Michelle
Villar, José
Stein, Alan
Staines Urias, Eleonora
Garza, Cutberto
Victora, Cesar G
Barros, Fernando C
Bertino, Enrico
Purwar, Manorama
Carvalho, Maria
Giuliani, Francesca
Wulff, Katharina
Abubakar, Amina A
Kihara, Michael
Cheikh Ismail, Leila
Aranzeta, Luis
Albernaz, Elaine
Kunnawar, Naina
Di Nicola, Paola
Ochieng, Roseline
Sandells, Tamsin
Savini, Sandy
Temple, Sophie
Murray, Elizabeth
Ohuma, Eric O
Gravett, Michael G
Pang, Ruyan
Jaffer, Yasmine A
Noble, Julia Alison
Winsey, Adele
Lambert, Ann
Papageorghiou, Aris T
Bhutta, Zulfiqar
Kennedy, Stephen
INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study
title INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study
title_full INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study
title_fullStr INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study
title_full_unstemmed INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study
title_short INTERGROWTH-21st Project international INTER-NDA standards for child development at 2 years of age: an international prospective population-based study
title_sort intergrowth-21st project international inter-nda standards for child development at 2 years of age: an international prospective population-based study
topic Paediatrics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282399/
https://www.ncbi.nlm.nih.gov/pubmed/32513882
http://dx.doi.org/10.1136/bmjopen-2019-035258
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