Clinical Significance of Various Classification Standards of Age Groups in Predicting Survival of Patients with Glioblastoma

BACKGROUND: The present study aimed to assess the association of various age groups with survival in patients with glioblastoma. MATERIAL/METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was used to extracted data on new diagnoses of glioblastoma between 2005 and 2015. Four age models were constructed according to the age at diagnosis. RESULTS: A total of 28 734 patients with glioblastoma (16 823 men and 11 911 women) were enrolled in the study. In multivariate analysis, variables including sex, race, tumor, and clinical information were identified as confounding factors to adjust 4 age models. In model 1, ages 39–58, 59–78, and 79+ years were risk factors of survival compared with age 0–18 years. In model 2, ages 18–65, 66–79, and 80+ years were prognostic factors of shorter survival compared with ages 0–17 years. In model 3, ages 45–59, 60–74, and 75+ years were associated with poor prognosis, while ages 18–44 years was associated with favorable clinical outcomes compared with ages 0–17 years. In model 4, ages 18–53, 54–64, and 65+ years were associated with poor prognosis. CONCLUSIONS: The differences in prognoses in different age groups of glioblastoma patients suggest that clinicians should incorporate age into routine clinical assessments and develop appropriate treatment strategies.