Cargando…

Crystal Structure of the SARS-CoV-2 Non-structural Protein 9, Nsp9

Many of the SARS-CoV-2 proteins have related counterparts across the Severe Acute Respiratory Syndrome (SARS-CoV) family. One such protein is non-structural protein 9 (Nsp9), which is thought to mediate viral replication, overall virulence, and viral genomic RNA reproduction. We sought to better cha...

Descripción completa

Detalles Bibliográficos
Autores principales:	Littler, Dene R., Gully, Benjamin S., Colson, Rhys N., Rossjohn, Jamie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282741/ https://www.ncbi.nlm.nih.gov/pubmed/32592996 http://dx.doi.org/10.1016/j.isci.2020.101258

Ejemplares similares

Binding of a pyrimidine RNA base-mimic to SARS-CoV-2 nonstructural protein 9
por: Littler, Dene R., et al.
Publicado: (2021)

Binding Studies of the Prodrug HAO472 to SARS-Cov-2 Nsp9 and Variants
por: Liu, Miaomiao, et al.
Publicado: (2022)

Inside-out: Antibody-binding reveals potential folding hinge-points within the SARS-CoV-2 replication co-factor nsp9
por: Pan, Yue, et al.
Publicado: (2023)

A natural product compound inhibits coronaviral replication in vitro by binding to the conserved Nsp9 SARS-CoV-2 protein
por: Littler, Dene R., et al.
Publicado: (2021)

A pocket guide on how to structure SARS-CoV-2 drugs and therapies
por: Littler, Dene R., et al.
Publicado: (2020)

Structural, energetic and lipophilic analysis of SARS-CoV-2 non-structural protein 9 (NSP9)
por: de O. Araújo, Jéssica, et al.
Publicado: (2021)

Crystal structures of pertussis toxin with NAD(+) and analogs provide structural insights into the mechanism of its cytosolic ADP-ribosylation activity
por: Sakari, Moona, et al.
Publicado: (2022)

Structural basis for the multimerization of nonstructural protein nsp9 from SARS-CoV-2
por: Zhang, Changhui, et al.
Publicado: (2020)

The crystal structure of nsp10-nsp16 heterodimer from SARS-CoV-2 in complex with S-adenosylmethionine
por: Rosas-Lemus, Monica, et al.
Publicado: (2020)

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
por: Kirchdoerfer, Robert N., et al.
Publicado: (2019)

Crystal structure of Nsp15 endoribonuclease NendoU from SARS‐CoV‐2
por: Kim, Youngchang, et al.
Publicado: (2020)

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity
por: Lin, Sheng, et al.
Publicado: (2021)

Crystal structure of SARS-CoV-2 nsp10/nsp16 2′-O-methylase and its implication on antiviral drug design
por: Lin, Sheng, et al.
Publicado: (2020)

Crystal structure of SARS‐CoV‐2 nsp10–nsp16 in complex with small molecule inhibitors, SS148 and WZ16
por: Klima, Martin, et al.
Publicado: (2022)

Insights into SARS-CoV transcription and replication from the structure of the nsp7–nsp8 hexadecamer
por: Zhai, Yujia, et al.
Publicado: (2005)

NMPylation and de-NMPylation of SARS-CoV-2 nsp9 by the NiRAN domain
por: Wang, Bing, et al.
Publicado: (2021)

The nsp9 Replicase Protein of SARS-Coronavirus, Structure and Functional Insights
por: Sutton, Geoff, et al.
Publicado: (2004)

Structural and Biochemical Characterization of the nsp12-nsp7-nsp8 Core Polymerase Complex from SARS-CoV-2
por: Peng, Qi, et al.
Publicado: (2020)

Cryo-EM Structures of the SARS-CoV-2 Endoribonuclease Nsp15
por: Pillon, Monica C., et al.
Publicado: (2020)

Multi-targeting approach for nsp3, nsp9, nsp12 and nsp15 proteins of SARS-CoV-2 by Diosmin as illustrated by molecular docking and molecular dynamics simulation methodologies
por: Kumar, Sumit, et al.
Publicado: (2021)

Resolving the Dynamic Motions of SARS-CoV-2 nsp7 and nsp8 Proteins Using Structural Proteomics
por: Courouble, Valentine V., et al.
Publicado: (2021)

Emerging Mutations in Nsp1 of SARS-CoV-2 and Their Effect on the Structural Stability
por: Mou, Kejie, et al.
Publicado: (2021)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

Substrate Specificity of SARS-CoV-2 Nsp10-Nsp16 Methyltransferase
por: Benoni, Roberto, et al.
Publicado: (2021)

Scalable Inhibitors of the Nsp3–Nsp4 Coupling in SARS-CoV-2
por: Azizogli, Abdul-Rahman, et al.
Publicado: (2023)

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
por: Shannon, Ashleigh, et al.
Publicado: (2020)

Structure, mechanism and crystallographic fragment screening of the SARS-CoV-2 NSP13 helicase
por: Newman, Joseph A., et al.
Publicado: (2021)

A distinct ssDNA/RNA binding interface in the Nsp9 protein from SARS‐CoV‐2
por: El‐Kamand, Serene, et al.
Publicado: (2021)

Backbone chemical shift spectral assignments of SARS coronavirus-2 non-structural protein nsp9
por: F. Dudás, Erika, et al.
Publicado: (2021)

Backbone chemical shift assignments for the SARS-CoV-2 non-structural protein Nsp9: intermediate (ms – μs) dynamics in the C-terminal helix at the dimer interface
por: Buchko, Garry W., et al.
Publicado: (2021)

A Computational Study on the Interaction of NSP10 and NSP14: Unraveling the RNA Synthesis Proofreading Mechanism in SARS-CoV-2, SARS-CoV, and MERS-CoV
por: Sarma, Himakshi, et al.
Publicado: (2022)

Structural basis for translational shutdown and immune evasion by the Nsp1 protein of SARS-CoV-2
por: Thoms, Matthias, et al.
Publicado: (2020)

Structure and Function of N-Terminal Zinc Finger Domain of SARS-CoV-2 NSP2
por: Ma, Jun, et al.
Publicado: (2021)

Artesunate induces substantial topological alterations in the SARS-CoV-2 Nsp1 protein structure
por: Gurung, Arun Bahadur, et al.
Publicado: (2022)

Structural Homology-Based Drug Repurposing Approach for Targeting NSP12 SARS-CoV-2
por: Aljuaid, Abdulelah, et al.
Publicado: (2022)

NSP9 of SARS-CoV-2 attenuates nuclear transport by hampering nucleoporin 62 dynamics and functions in host cells
por: Makiyama, Kei, et al.
Publicado: (2022)

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
por: Yuen, Chun-Kit, et al.
Publicado: (2020)

NMR assignment of the SARS-CoV protein nsp1
por: Almeida, M. S., et al.
Publicado: (2006)

In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors
por: Gurung, Arun Bahadur
Publicado: (2020)

Computational Investigation of Structural Dynamics of SARS-CoV-2 Methyltransferase-Stimulatory Factor Heterodimer nsp16/nsp10 Bound to the Cofactor SAM
por: Sk, Md Fulbabu, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_aacvi8p0ieok5mqvqln3cnvte3