Repositioning of pentoxifylline as an immunomodulator and regulator of the renin-angiotensin system in the treatment of COVID-19

Pentoxifylline (PTX) is a phosphodiesterase inhibitor that increases cyclic adenosine monophosphate levels, which in turn activate protein kinase, leading to a reduction in the synthesis of proinflammatory cytokines to ultimately influence the renin-angiotensin system (RAS) in vitro by inhibiting an...

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Detalles Bibliográficos
Autores principales: Maldonado, Valente, Loza-Mejía, Marco A., Chávez-Alderete, Jaime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282759/
https://www.ncbi.nlm.nih.gov/pubmed/32540603
http://dx.doi.org/10.1016/j.mehy.2020.109988

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