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Maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the Generation R Study
BACKGROUND: Evidence suggests that low birth weight and fetal exposure to extreme maternal undernutrition is associated with cardiovascular disease in adulthood. Hyperemesis gravidarum, a clinical entity characterized by severe nausea and excess vomiting leading to a suboptimal maternal nutritional...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cambridge University Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282857/ https://www.ncbi.nlm.nih.gov/pubmed/31474237 http://dx.doi.org/10.1017/S2040174419000114 |
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author | Poeran - Bahadoer, Sunayna Jaddoe, Vincent W. V. Gishti, Olta Grooten, Iris J. Franco, Oscar H. Hofman, Albert Steegers, Eric A. P. Gaillard, Romy |
author_facet | Poeran - Bahadoer, Sunayna Jaddoe, Vincent W. V. Gishti, Olta Grooten, Iris J. Franco, Oscar H. Hofman, Albert Steegers, Eric A. P. Gaillard, Romy |
author_sort | Poeran - Bahadoer, Sunayna |
collection | PubMed |
description | BACKGROUND: Evidence suggests that low birth weight and fetal exposure to extreme maternal undernutrition is associated with cardiovascular disease in adulthood. Hyperemesis gravidarum, a clinical entity characterized by severe nausea and excess vomiting leading to a suboptimal maternal nutritional status during early pregnancy, is associated with an increased risk of adverse pregnancy outcomes. Several studies also showed that different measures related to hyperemesis gravidarum, such as maternal daily vomiting or severe weight loss, are associated with increased risks of adverse fetal pregnancy outcomes. Not much is known about long-term offspring consequences of maternal hyperemesis gravidarum and related measures during pregnancy. We examined the associations of maternal daily vomiting during early pregnancy, as a measure related to hyperemesis gravidarum, with childhood cardiovascular risk factors. METHODS: In a population-based prospective cohort study from early pregnancy onwards among 4,769 mothers and their children in Rotterdam, the Netherlands, we measured childhood body mass index, total fat mass percentage, android/gynoid fat mass ratio, preperitoneal fat mass area, blood pressure, lipids, and insulin levels. We used multiple regression analyses to assess the associations of maternal vomiting during early pregnancy with childhood cardiovascular outcomes. RESULTS: Compared with the children of mothers without daily vomiting during early pregnancy, the children of mothers with daily vomiting during early pregnancy had a higher childhood total body fat mass (difference 0.12 standard deviation score [SDS]; 95% confidence interval [CI] 0.03–0.20), android/gynoid fat mass ratio (difference 0.13 SDS; 95% CI 0.04–0.23), and preperitoneal fat mass area (difference 0.10 SDS; 95% CI 0–0.20). These associations were not explained by birth characteristics but partly explained by higher infant growth. Maternal daily vomiting during early pregnancy was not associated with childhood blood pressure, lipids, and insulin levels. CONCLUSIONS: Maternal daily vomiting during early pregnancy is associated with higher childhood total body fat mass and abdominal fat mass levels, but not with other cardiovascular risk factors. Further studies are needed to replicate these findings, to explore the underlying mechanisms and to assess the long-term consequences. |
format | Online Article Text |
id | pubmed-7282857 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Cambridge University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-72828572020-06-17 Maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the Generation R Study Poeran - Bahadoer, Sunayna Jaddoe, Vincent W. V. Gishti, Olta Grooten, Iris J. Franco, Oscar H. Hofman, Albert Steegers, Eric A. P. Gaillard, Romy J Dev Orig Health Dis Original Article BACKGROUND: Evidence suggests that low birth weight and fetal exposure to extreme maternal undernutrition is associated with cardiovascular disease in adulthood. Hyperemesis gravidarum, a clinical entity characterized by severe nausea and excess vomiting leading to a suboptimal maternal nutritional status during early pregnancy, is associated with an increased risk of adverse pregnancy outcomes. Several studies also showed that different measures related to hyperemesis gravidarum, such as maternal daily vomiting or severe weight loss, are associated with increased risks of adverse fetal pregnancy outcomes. Not much is known about long-term offspring consequences of maternal hyperemesis gravidarum and related measures during pregnancy. We examined the associations of maternal daily vomiting during early pregnancy, as a measure related to hyperemesis gravidarum, with childhood cardiovascular risk factors. METHODS: In a population-based prospective cohort study from early pregnancy onwards among 4,769 mothers and their children in Rotterdam, the Netherlands, we measured childhood body mass index, total fat mass percentage, android/gynoid fat mass ratio, preperitoneal fat mass area, blood pressure, lipids, and insulin levels. We used multiple regression analyses to assess the associations of maternal vomiting during early pregnancy with childhood cardiovascular outcomes. RESULTS: Compared with the children of mothers without daily vomiting during early pregnancy, the children of mothers with daily vomiting during early pregnancy had a higher childhood total body fat mass (difference 0.12 standard deviation score [SDS]; 95% confidence interval [CI] 0.03–0.20), android/gynoid fat mass ratio (difference 0.13 SDS; 95% CI 0.04–0.23), and preperitoneal fat mass area (difference 0.10 SDS; 95% CI 0–0.20). These associations were not explained by birth characteristics but partly explained by higher infant growth. Maternal daily vomiting during early pregnancy was not associated with childhood blood pressure, lipids, and insulin levels. CONCLUSIONS: Maternal daily vomiting during early pregnancy is associated with higher childhood total body fat mass and abdominal fat mass levels, but not with other cardiovascular risk factors. Further studies are needed to replicate these findings, to explore the underlying mechanisms and to assess the long-term consequences. Cambridge University Press 2019-09-02 2020-04 /pmc/articles/PMC7282857/ /pubmed/31474237 http://dx.doi.org/10.1017/S2040174419000114 Text en © Cambridge University Press and the International Society for Developmental Origins of Health and Disease 2019 http://creativecommons.org/licenses/by/4.0/ This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Poeran - Bahadoer, Sunayna Jaddoe, Vincent W. V. Gishti, Olta Grooten, Iris J. Franco, Oscar H. Hofman, Albert Steegers, Eric A. P. Gaillard, Romy Maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the Generation R Study |
title | Maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the Generation R Study |
title_full | Maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the Generation R Study |
title_fullStr | Maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the Generation R Study |
title_full_unstemmed | Maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the Generation R Study |
title_short | Maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the Generation R Study |
title_sort | maternal vomiting during early pregnancy and cardiovascular risk factors at school age: the generation r study |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7282857/ https://www.ncbi.nlm.nih.gov/pubmed/31474237 http://dx.doi.org/10.1017/S2040174419000114 |
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