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An unexpected death after low anterior resection due to disseminated intravascular coagulation: A case report

INTRODUCTION: Disseminated intravascular coagulation (DIC) is a blood clotting disorder that is characterized by intravascular thrombi formation and exhaustion of platelets and coagulation factors resulting in diffuse hemorrhage and multiple organ dysfunction. PRESENTATION OF CASE: We present a case...

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Detalles Bibliográficos
Autores principales: Kosir, Jurij Ales, Salihovic, Mensur, Sever, Primoz, Klen, Jasna
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283093/
https://www.ncbi.nlm.nih.gov/pubmed/32506007
http://dx.doi.org/10.1016/j.ijscr.2020.05.045
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author Kosir, Jurij Ales
Salihovic, Mensur
Sever, Primoz
Klen, Jasna
author_facet Kosir, Jurij Ales
Salihovic, Mensur
Sever, Primoz
Klen, Jasna
author_sort Kosir, Jurij Ales
collection PubMed
description INTRODUCTION: Disseminated intravascular coagulation (DIC) is a blood clotting disorder that is characterized by intravascular thrombi formation and exhaustion of platelets and coagulation factors resulting in diffuse hemorrhage and multiple organ dysfunction. PRESENTATION OF CASE: We present a case report of a previously healthy middle-aged patient who was treated by low anterior resection for rectal carcinoma and suddenly went into unexpected circulatory shock on the 7th postoperative day. Despite our resuscitation efforts, he succumbed to the disease. The postmortem examination showed findings consistent with DIC. DISCUSSION: The cause for DIC in this patient may be multifactorial. Sepsis, tumor-related factors and hereditary predisposition may have played a role. The role of blood components in treatment is not fully understood as they may worsen the inflammatory response. CONCLUSION: DIC can be the presenting sign of unrecognized sepsis and it can occur in all surgical patients. Even with prompt treatment, the disease can have a fatal course.
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spelling pubmed-72830932020-06-10 An unexpected death after low anterior resection due to disseminated intravascular coagulation: A case report Kosir, Jurij Ales Salihovic, Mensur Sever, Primoz Klen, Jasna Int J Surg Case Rep Article INTRODUCTION: Disseminated intravascular coagulation (DIC) is a blood clotting disorder that is characterized by intravascular thrombi formation and exhaustion of platelets and coagulation factors resulting in diffuse hemorrhage and multiple organ dysfunction. PRESENTATION OF CASE: We present a case report of a previously healthy middle-aged patient who was treated by low anterior resection for rectal carcinoma and suddenly went into unexpected circulatory shock on the 7th postoperative day. Despite our resuscitation efforts, he succumbed to the disease. The postmortem examination showed findings consistent with DIC. DISCUSSION: The cause for DIC in this patient may be multifactorial. Sepsis, tumor-related factors and hereditary predisposition may have played a role. The role of blood components in treatment is not fully understood as they may worsen the inflammatory response. CONCLUSION: DIC can be the presenting sign of unrecognized sepsis and it can occur in all surgical patients. Even with prompt treatment, the disease can have a fatal course. Elsevier 2020-05-29 /pmc/articles/PMC7283093/ /pubmed/32506007 http://dx.doi.org/10.1016/j.ijscr.2020.05.045 Text en © 2020 Published by Elsevier Ltd on behalf of IJS Publishing Group Ltd. http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kosir, Jurij Ales
Salihovic, Mensur
Sever, Primoz
Klen, Jasna
An unexpected death after low anterior resection due to disseminated intravascular coagulation: A case report
title An unexpected death after low anterior resection due to disseminated intravascular coagulation: A case report
title_full An unexpected death after low anterior resection due to disseminated intravascular coagulation: A case report
title_fullStr An unexpected death after low anterior resection due to disseminated intravascular coagulation: A case report
title_full_unstemmed An unexpected death after low anterior resection due to disseminated intravascular coagulation: A case report
title_short An unexpected death after low anterior resection due to disseminated intravascular coagulation: A case report
title_sort unexpected death after low anterior resection due to disseminated intravascular coagulation: a case report
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283093/
https://www.ncbi.nlm.nih.gov/pubmed/32506007
http://dx.doi.org/10.1016/j.ijscr.2020.05.045
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