Unbiased yeast screens identify cellular pathways affected in Niemann–Pick disease type C

Niemann–Pick disease type C (NPC) is a rare lysosomal storage disease caused by mutations in either the NPC1 or NPC2 genes. Mutations in the NPC1 gene lead to the majority of clinical cases (95%); however, the function of NPC1 remains unknown. To gain further insights into the biology of NPC1, we to...

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Detalles Bibliográficos
Autores principales: Colaco, Alexandria, Fernández-Suárez, María E, Shepherd, Dawn, Gal, Lihi, Bibi, Chen, Chuartzman, Silvia, Diot, Alan, Morten, Karl, Eden, Emily, Porter, Forbes D, Poulton, Joanna, Platt, Nick, Schuldiner, Maya, Platt, Frances M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283134/
https://www.ncbi.nlm.nih.gov/pubmed/32487688
http://dx.doi.org/10.26508/lsa.201800253

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