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Non-Newtonian droplet-based microfluidics logic gates

Droplet-based microfluidic logic gates have many applications in diagnostic assays and biosciences due to their automation and the ability to be cascaded. In spite of many bio-fluids, such as blood exhibit non-Newtonian characteristics, all the previous studies have been concerned with the Newtonian...

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Autores principales: Asghari, Elmira, Moosavi, Ali, Hannani, Siamak Kazemzadeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283233/
https://www.ncbi.nlm.nih.gov/pubmed/32518389
http://dx.doi.org/10.1038/s41598-020-66337-7
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author Asghari, Elmira
Moosavi, Ali
Hannani, Siamak Kazemzadeh
author_facet Asghari, Elmira
Moosavi, Ali
Hannani, Siamak Kazemzadeh
author_sort Asghari, Elmira
collection PubMed
description Droplet-based microfluidic logic gates have many applications in diagnostic assays and biosciences due to their automation and the ability to be cascaded. In spite of many bio-fluids, such as blood exhibit non-Newtonian characteristics, all the previous studies have been concerned with the Newtonian fluids. Moreover, none of the previous studies has investigated the operating regions of the logic gates. In this research, we consider a typical AND/OR logic gate with a power-law fluid. We study the effects of important parameters such as the power-law index, the droplet length, the capillary number, and the geometrical parameters of the microfluidic system on the operating regions of the system. The results indicate that AND/OR states mechanism function in opposite directions. By increasing the droplet length, the capillary number and the power-law index, the operating region of AND state increases while the operating region of OR state reduces. Increasing the channel width will decrease the operating region of AND state while it increases the operating region of OR state. For proper operation of the logic gate, it should work in both AND/OR states appropriately. By combining the operating regions of these two states, the overall operating region of the logic gate is achieved.
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spelling pubmed-72832332020-06-15 Non-Newtonian droplet-based microfluidics logic gates Asghari, Elmira Moosavi, Ali Hannani, Siamak Kazemzadeh Sci Rep Article Droplet-based microfluidic logic gates have many applications in diagnostic assays and biosciences due to their automation and the ability to be cascaded. In spite of many bio-fluids, such as blood exhibit non-Newtonian characteristics, all the previous studies have been concerned with the Newtonian fluids. Moreover, none of the previous studies has investigated the operating regions of the logic gates. In this research, we consider a typical AND/OR logic gate with a power-law fluid. We study the effects of important parameters such as the power-law index, the droplet length, the capillary number, and the geometrical parameters of the microfluidic system on the operating regions of the system. The results indicate that AND/OR states mechanism function in opposite directions. By increasing the droplet length, the capillary number and the power-law index, the operating region of AND state increases while the operating region of OR state reduces. Increasing the channel width will decrease the operating region of AND state while it increases the operating region of OR state. For proper operation of the logic gate, it should work in both AND/OR states appropriately. By combining the operating regions of these two states, the overall operating region of the logic gate is achieved. Nature Publishing Group UK 2020-06-09 /pmc/articles/PMC7283233/ /pubmed/32518389 http://dx.doi.org/10.1038/s41598-020-66337-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Asghari, Elmira
Moosavi, Ali
Hannani, Siamak Kazemzadeh
Non-Newtonian droplet-based microfluidics logic gates
title Non-Newtonian droplet-based microfluidics logic gates
title_full Non-Newtonian droplet-based microfluidics logic gates
title_fullStr Non-Newtonian droplet-based microfluidics logic gates
title_full_unstemmed Non-Newtonian droplet-based microfluidics logic gates
title_short Non-Newtonian droplet-based microfluidics logic gates
title_sort non-newtonian droplet-based microfluidics logic gates
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283233/
https://www.ncbi.nlm.nih.gov/pubmed/32518389
http://dx.doi.org/10.1038/s41598-020-66337-7
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