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Reversal of glucocorticoid resistance in paediatric acute lymphoblastic leukaemia is dependent on restoring BIM expression

BACKGROUND: Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Glucocorticoids form a critical component of chemotherapy regimens and resistance to glucocorticoid therapy is predictive of poor outcome. We have previously shown that glucocorticoid resistance is associated w...

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Detalles Bibliográficos
Autores principales:	Toscan, Cara E., Jing, Duohui, Mayoh, Chelsea, Lock, Richard B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283241/ https://www.ncbi.nlm.nih.gov/pubmed/32242100 http://dx.doi.org/10.1038/s41416-020-0824-8

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