Cargando…

The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

The cytokine tumor necrosis factor-alpha (TNF-α) readily forms homotrimers at sub-nM concentrations to promote inflammation. For the treatment of inflammatory diseases with upregulated levels of TNF-α, a number of therapeutic antibodies are currently used as scavengers to reduce the active TNF-α con...

Descripción completa

Detalles Bibliográficos
Autores principales:	Daub, Herwin, Traxler, Lukas, Ismajli, Fjolla, Groitl, Bastian, Itzen, Aymelt, Rant, Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283243/ https://www.ncbi.nlm.nih.gov/pubmed/32518229 http://dx.doi.org/10.1038/s41598-020-66123-5

Ejemplares similares

Validation of the Slow Off‐Kinetics of Sirtuin‐Rearranging Ligands (SirReals) by Means of Label‐Free Electrically Switchable Nanolever Technology
por: Schiedel, Matthias, et al.
Publicado: (2020)

Polymerase/DNA interactions and enzymatic activity: multi-parameter analysis with electro-switchable biosurfaces
por: Langer, Andreas, et al.
Publicado: (2015)

A monomer-trimer model supports intermittent glucagon fibril growth
por: Košmrlj, Andrej, et al.
Publicado: (2015)

Therapeutic TNF Inhibitors can Differentially Stabilize Trimeric TNF by Inhibiting Monomer Exchange
por: van Schie, Karin A., et al.
Publicado: (2016)

Spectral Signatures of Protonated Noble Gas Clusters of Ne, Ar, Kr, and Xe: From Monomers to Trimers
por: Tan, Jake A., et al.
Publicado: (2022)

The protease GtgE from Salmonella exclusively targets inactive Rab GTPases
por: Wachtel, Rudolf, et al.
Publicado: (2018)

Adenylylation of Tyr77 stabilizes Rab1b GTPase in an active state: A molecular dynamics simulation analysis
por: Luitz, Manuel P., et al.
Publicado: (2016)

A DNA-Based Biosensor Assay for the Kinetic Characterization of Ion-Dependent Aptamer Folding and Protein Binding
por: Ponzo, Irene, et al.
Publicado: (2019)

Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation
por: Höpfner, Dorothea, et al.
Publicado: (2020)

Monoclonal Anti-AMP Antibodies Are Sensitive and Valuable Tools for Detecting Patterns of AMPylation
por: Höpfner, Dorothea, et al.
Publicado: (2021)

Monomers, dimers, and trimers of [Au(CN)(2)](−) in a Ba(diaza-18-crown-6)(2+) coordination polymer
por: Beavers, Christine M., et al.
Publicado: (2009)

Legionella effector AnkX displaces the switch II region for Rab1b phosphocholination
por: Ernst, Stefan, et al.
Publicado: (2020)

The Alarmone Diadenosine Tetraphosphate as a Cosubstrate for Protein AMPylation
por: Frese, Matthias, et al.
Publicado: (2023)

Clinical significance of tumor necrosis factor-alpha and carcinoembryonic antigen in gastric cancer
por: Roșu, Mihai Cătălin, et al.
Publicado: (2022)

Atomic resolution structure of EhpR: phenazine resistance in Enterobacter agglomerans Eh1087 follows principles of bleomycin/mitomycin C resistance in other bacteria
por: Yu, Shen, et al.
Publicado: (2011)

Diversity and plasticity in Rab GTPase nucleotide release mechanism has consequences for Rab activation and inactivation
por: Langemeyer, Lars, et al.
Publicado: (2014)

MOMP from Campylobacter jejuni Is a Trimer of 18-Stranded β-Barrel Monomers with a Ca(2 +) Ion Bound at the Constriction Zone
por: Ferrara, Luana G M, et al.
Publicado: (2016)

Serum Tumor Necrosis Factor-Alpha Levels in Acute Leukemia and Its Prognostic Significance
por: Verma, Sapana, et al.
Publicado: (2022)

A Trimeric Lipoprotein Assists in Trimeric Autotransporter Biogenesis in Enterobacteria
por: Grin, Iwan, et al.
Publicado: (2014)

RabGEFs are a major determinant for specific Rab membrane targeting
por: Blümer, Julia, et al.
Publicado: (2013)

Covalent Triazine Frameworks Based on the First Pseudo-Octahedral Hexanitrile Monomer via Nitrile Trimerization: Synthesis, Porosity, and CO(2) Gas Sorption Properties
por: Wessely, Isabelle D., et al.
Publicado: (2021)

Monomer-Shuffling and Allosteric Transition in KaiC Circadian Oscillation
por: Yoda, Mitsumasa, et al.
Publicado: (2007)

Classification and monomer-by-monomer annotation dataset of suprachromosomal family 1 alpha satellite higher-order repeats in hg38 human genome assembly
por: Uralsky, L.I., et al.
Publicado: (2019)

Dephosphocholination by Legionella effector Lem3 functions through remodelling of the switch II region of Rab1b
por: Kaspers, Marietta S., et al.
Publicado: (2023)

Quantum Computational, Spectroscopic (FT-IR, FT-Raman, NMR, and UV–Vis) Hirshfeld Surface and Molecular Docking-Dynamics Studies on 5-Hydroxymethyluracil (Monomer and Trimer)
por: Kumar, Mohit, et al.
Publicado: (2023)

Trimeric Structure of Langerin
por: Feinberg, Hadar, et al.
Publicado: (2010)

PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72
por: Vieweg, Sophie, et al.
Publicado: (2020)

Structural insights into the BRAF monomer-to-dimer transition mediated by RAS binding
por: Martinez Fiesco, Juliana A., et al.
Publicado: (2022)

Monomer and Oligomer Transition of Zinc Phthalocyanine Is Key for Photobleaching in Photodynamic Therapy
por: Liu, Dafeng, et al.
Publicado: (2023)

Significance of Vascular Cell Adhesion Molecule-1 and Tumor Necrosis Factor-Alpha in HIV-Infected Patients
por: Mikuła, Tomasz, et al.
Publicado: (2022)

Perturbation of the Monomer–Monomer Interfaces of the Benzoylformate Decarboxylase Tetramer
por: Andrews, Forest H., et al.
Publicado: (2014)

Locking GTPases covalently in their functional states
por: Wiegandt, David, et al.
Publicado: (2015)

bMERB domains are bivalent Rab8 family effectors evolved by gene duplication
por: Rai, Amrita, et al.
Publicado: (2016)

Rab1-AMPylation by Legionella DrrA is allosterically activated by Rab1
por: Du, Jiqing, et al.
Publicado: (2021)

Smart Homopolymer Microgels: Influence of the Monomer Structure on the Particle Properties
por: Wedel, Bastian, et al.
Publicado: (2016)

Proteolysis of Rab32 by Salmonella GtgE induces an inactive GTPase conformation
por: Savitskiy, Sergey, et al.
Publicado: (2020)

Endogenous alpha-synuclein monomers, oligomers and resulting pathology: let’s talk about the lipids in the room
por: Killinger, Bryan A., et al.
Publicado: (2019)

Pillararenes Trimer for Self-Assembly
por: Zhang, Huacheng, et al.
Publicado: (2020)

Induced Expression of Trimerized Intracellular Domains of the Human Tumor Necrosis Factor (TNF) p55 Receptor Elicits TNF Effects
por: Vandevoorde, Veronique, et al.
Publicado: (1997)

Tumor Necrosis Factor Alpha Signaling and Organogenesis
por: You, Kai, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_bblun61kd3h9l8fplg3f6r4vvk