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The trimer to monomer transition of Tumor Necrosis Factor-Alpha is a dynamic process that is significantly altered by therapeutic antibodies

The cytokine tumor necrosis factor-alpha (TNF-α) readily forms homotrimers at sub-nM concentrations to promote inflammation. For the treatment of inflammatory diseases with upregulated levels of TNF-α, a number of therapeutic antibodies are currently used as scavengers to reduce the active TNF-α con...

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Detalles Bibliográficos
Autores principales:	Daub, Herwin, Traxler, Lukas, Ismajli, Fjolla, Groitl, Bastian, Itzen, Aymelt, Rant, Ulrich
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283243/ https://www.ncbi.nlm.nih.gov/pubmed/32518229 http://dx.doi.org/10.1038/s41598-020-66123-5

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