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Prophylactic effect of flavanol rich preparation metabolites in promoting resilience to a mouse model of social stress

Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in experimental models. Inflammatory cytokine interleukin-6 (...

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Detalles Bibliográficos
Autores principales: Wang, Jun, Zhao, Danyue, Tiano, Simoni, Esteban-Fernández, Adelaida, Yuan, Bo, Smith, Chad, Brathwaite, Justin, Jlayer, Zahra, Wu, Qingli, Simon, James E., Trageser, Kyle J., Pasinetti, Giulio M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283298/
https://www.ncbi.nlm.nih.gov/pubmed/32518327
http://dx.doi.org/10.1038/s41398-020-0859-x
Descripción
Sumario:Major depressive disorder (MDD) is a leading cause of disability, and there is an urgent need for new therapeutics. Stress-mediated induction of pro-inflammation in the periphery contributes to depression-like behaviors both in humans and in experimental models. Inflammatory cytokine interleukin-6 (IL-6) has emerged as a potential therapeutic target. Our studies demonstrated that metabolism of flavanol rich cocoa preparation (FRP) led to the accumulation of select phenolic acids that may contribute to its anti-inflammatory activity. Using a repeated social defeat stress (RSDS) model of depression, we showed that oral administration of FRP attenuates susceptibility to RSDS-mediated depression, supporting the further development of FRP as a novel therapeutic for the treatment of stress disorders and anxiety in humans.