convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting

We have developed a chimeric antigen receptor (CAR) platform that functions as a modular system to address limitations of traditional CAR therapies. An inert form of the human NKG2D extracellular domain (iNKG2D) was engineered as the ectodomain of the CAR to generate convertibleCAR(TM)-T cells. Thes...

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Detalles Bibliográficos
Autores principales: Landgraf, Kyle E., Williams, Steven R., Steiger, Daniel, Gebhart, Dana, Lok, Stephen, Martin, David W., Roybal, Kole T., Kim, Kaman Chan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283332/
https://www.ncbi.nlm.nih.gov/pubmed/32518350
http://dx.doi.org/10.1038/s42003-020-1021-2

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