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Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study
Anticholinergic burden has been widely studied in specific patient populations with specific conditions. However, the prevalence in the general population is poorly understood. This retrospective cross-sectional study was a nationwide database analysis of outpatient prescriptions of anticholinergic...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283335/ https://www.ncbi.nlm.nih.gov/pubmed/32518392 http://dx.doi.org/10.1038/s41598-020-65989-9 |
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author | Cebron Lipovec, Nanca Jazbar, Janja Kos, Mitja |
author_facet | Cebron Lipovec, Nanca Jazbar, Janja Kos, Mitja |
author_sort | Cebron Lipovec, Nanca |
collection | PubMed |
description | Anticholinergic burden has been widely studied in specific patient populations with specific conditions. However, the prevalence in the general population is poorly understood. This retrospective cross-sectional study was a nationwide database analysis of outpatient prescriptions of anticholinergic medications. The study was based on Slovenian health claims data of all outpatient prescriptions in 2018. Anticholinergic burden was evaluated using the Anticholinergic Cognitive Burden scale. Three age groups were analysed: children (≤18 years), adults (19–64 years) and older adults (≥65 years). Anticholinergic medications were prescribed to 29.8% of the participants; 7.6% were exposed to a clinically significant anticholinergic burden. The proportion of patients exposed to anticholinergic burden was highest in older adults (43.2%), followed by adults (25.8%) and children (20.7%). The most frequently prescribed medications with the highest anticholinergic activity were antipsychotics and medications for urinary diseases (42.8% and 40.2%, respectively). Medications with second highest activity were mostly antiepileptics (87.3%). Medications with possible anticholinergic activity included diverse therapeutic groups. Anticholinergic burden is highest in older adults but is also considerable among adults and children. Medications with anticholinergic activity belong to diverse therapeutic groups. Further research is needed on safe use of these medications in all age groups. |
format | Online Article Text |
id | pubmed-7283335 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-72833352020-06-15 Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study Cebron Lipovec, Nanca Jazbar, Janja Kos, Mitja Sci Rep Article Anticholinergic burden has been widely studied in specific patient populations with specific conditions. However, the prevalence in the general population is poorly understood. This retrospective cross-sectional study was a nationwide database analysis of outpatient prescriptions of anticholinergic medications. The study was based on Slovenian health claims data of all outpatient prescriptions in 2018. Anticholinergic burden was evaluated using the Anticholinergic Cognitive Burden scale. Three age groups were analysed: children (≤18 years), adults (19–64 years) and older adults (≥65 years). Anticholinergic medications were prescribed to 29.8% of the participants; 7.6% were exposed to a clinically significant anticholinergic burden. The proportion of patients exposed to anticholinergic burden was highest in older adults (43.2%), followed by adults (25.8%) and children (20.7%). The most frequently prescribed medications with the highest anticholinergic activity were antipsychotics and medications for urinary diseases (42.8% and 40.2%, respectively). Medications with second highest activity were mostly antiepileptics (87.3%). Medications with possible anticholinergic activity included diverse therapeutic groups. Anticholinergic burden is highest in older adults but is also considerable among adults and children. Medications with anticholinergic activity belong to diverse therapeutic groups. Further research is needed on safe use of these medications in all age groups. Nature Publishing Group UK 2020-06-09 /pmc/articles/PMC7283335/ /pubmed/32518392 http://dx.doi.org/10.1038/s41598-020-65989-9 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Cebron Lipovec, Nanca Jazbar, Janja Kos, Mitja Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study |
title | Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study |
title_full | Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study |
title_fullStr | Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study |
title_full_unstemmed | Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study |
title_short | Anticholinergic Burden in Children, Adults and Older Adults in Slovenia: A Nationwide Database Study |
title_sort | anticholinergic burden in children, adults and older adults in slovenia: a nationwide database study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283335/ https://www.ncbi.nlm.nih.gov/pubmed/32518392 http://dx.doi.org/10.1038/s41598-020-65989-9 |
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