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Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity
Homeostatic regulation of cardiomyocytes plays a crucial role in maintaining the normal physiological activity of cardiac tissue. Severe cardiotoxicity results in cardiac diseases including but not limited to arrhythmia, myocardial infarction and myocardial hypertrophy. Drug-induced cardiotoxicity l...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283551/ https://www.ncbi.nlm.nih.gov/pubmed/32582710 http://dx.doi.org/10.3389/fcell.2020.00434 |
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author | Ma, Wanjun Wei, Shanshan Zhang, Bikui Li, Wenqun |
author_facet | Ma, Wanjun Wei, Shanshan Zhang, Bikui Li, Wenqun |
author_sort | Ma, Wanjun |
collection | PubMed |
description | Homeostatic regulation of cardiomyocytes plays a crucial role in maintaining the normal physiological activity of cardiac tissue. Severe cardiotoxicity results in cardiac diseases including but not limited to arrhythmia, myocardial infarction and myocardial hypertrophy. Drug-induced cardiotoxicity limits or forbids further use of the implicated drugs. Such drugs that are currently available in the clinic include anti-tumor drugs (doxorubicin, cisplatin, trastuzumab, etc.), antidiabetic drugs (rosiglitazone and pioglitazone), and an antiviral drug (zidovudine). This review focused on cardiomyocyte death forms and related mechanisms underlying clinical drug-induced cardiotoxicity, including apoptosis, autophagy, necrosis, necroptosis, pryoptosis, and ferroptosis. The key proteins involved in cardiomyocyte death signaling were discussed and evaluated, aiming to provide a theoretical basis and target for the prevention and treatment of drug-induced cardiotoxicity in the clinical practice. |
format | Online Article Text |
id | pubmed-7283551 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72835512020-06-23 Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity Ma, Wanjun Wei, Shanshan Zhang, Bikui Li, Wenqun Front Cell Dev Biol Cell and Developmental Biology Homeostatic regulation of cardiomyocytes plays a crucial role in maintaining the normal physiological activity of cardiac tissue. Severe cardiotoxicity results in cardiac diseases including but not limited to arrhythmia, myocardial infarction and myocardial hypertrophy. Drug-induced cardiotoxicity limits or forbids further use of the implicated drugs. Such drugs that are currently available in the clinic include anti-tumor drugs (doxorubicin, cisplatin, trastuzumab, etc.), antidiabetic drugs (rosiglitazone and pioglitazone), and an antiviral drug (zidovudine). This review focused on cardiomyocyte death forms and related mechanisms underlying clinical drug-induced cardiotoxicity, including apoptosis, autophagy, necrosis, necroptosis, pryoptosis, and ferroptosis. The key proteins involved in cardiomyocyte death signaling were discussed and evaluated, aiming to provide a theoretical basis and target for the prevention and treatment of drug-induced cardiotoxicity in the clinical practice. Frontiers Media S.A. 2020-06-03 /pmc/articles/PMC7283551/ /pubmed/32582710 http://dx.doi.org/10.3389/fcell.2020.00434 Text en Copyright © 2020 Ma, Wei, Zhang and Li. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Ma, Wanjun Wei, Shanshan Zhang, Bikui Li, Wenqun Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity |
title | Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity |
title_full | Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity |
title_fullStr | Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity |
title_full_unstemmed | Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity |
title_short | Molecular Mechanisms of Cardiomyocyte Death in Drug-Induced Cardiotoxicity |
title_sort | molecular mechanisms of cardiomyocyte death in drug-induced cardiotoxicity |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283551/ https://www.ncbi.nlm.nih.gov/pubmed/32582710 http://dx.doi.org/10.3389/fcell.2020.00434 |
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