Brain-derived neurotrophic factor and mental disorders

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged fro...

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Detalles Bibliográficos
Autores principales: Lin, Chin-Chuen, Huang, Tiao-Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chang Gung University 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283564/
https://www.ncbi.nlm.nih.gov/pubmed/32386841
http://dx.doi.org/10.1016/j.bj.2020.01.001
Descripción
Sumario:Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder.

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