Brain-derived neurotrophic factor and mental disorders

Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged fro...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Chin-Chuen, Huang, Tiao-Lai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chang Gung University 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283564/
https://www.ncbi.nlm.nih.gov/pubmed/32386841
http://dx.doi.org/10.1016/j.bj.2020.01.001
_version_ 1783544328450211840
author Lin, Chin-Chuen
Huang, Tiao-Lai
author_facet Lin, Chin-Chuen
Huang, Tiao-Lai
author_sort Lin, Chin-Chuen
collection PubMed
description Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder.
format Online
Article
Text
id pubmed-7283564
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Chang Gung University
record_format MEDLINE/PubMed
spelling pubmed-72835642020-06-15 Brain-derived neurotrophic factor and mental disorders Lin, Chin-Chuen Huang, Tiao-Lai Biomed J Review Article Brain-derived neurotrophic factor (BDNF) is a neurotrophin that modulates neuroplasticity in the brain, and is one of the most widely investigated molecule in psychiatric disorders. The researches of BDNF emcompassed the advance of investigative techniques of past decades. BDNF researches ranged from protein quantilization, to RNA expression measurements, to DNA sequencing, and lately but not lastly, epigenetic studies. In this review, we will briefly address findings on BDNF protein levels, mRNA expression, Val66Met polymorphism, and epigenetic modifications, in schizophrenia, major depressive disorder (MDD), and bipolar disorder. Chang Gung University 2020-04 2020-05-05 /pmc/articles/PMC7283564/ /pubmed/32386841 http://dx.doi.org/10.1016/j.bj.2020.01.001 Text en © 2020 Chang Gung University. Publishing services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Review Article
Lin, Chin-Chuen
Huang, Tiao-Lai
Brain-derived neurotrophic factor and mental disorders
title Brain-derived neurotrophic factor and mental disorders
title_full Brain-derived neurotrophic factor and mental disorders
title_fullStr Brain-derived neurotrophic factor and mental disorders
title_full_unstemmed Brain-derived neurotrophic factor and mental disorders
title_short Brain-derived neurotrophic factor and mental disorders
title_sort brain-derived neurotrophic factor and mental disorders
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283564/
https://www.ncbi.nlm.nih.gov/pubmed/32386841
http://dx.doi.org/10.1016/j.bj.2020.01.001
work_keys_str_mv AT linchinchuen brainderivedneurotrophicfactorandmentaldisorders
AT huangtiaolai brainderivedneurotrophicfactorandmentaldisorders

Ejemplares similares