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The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness
Cancer stemness represents one of the major mechanisms that predispose patients to tumor aggressiveness, metastasis, and treatment resistance. MicroRNA biogenesis is an important process controlling miRNA processing and maturation. Deregulation of miRNA biogenesis can lead to tumorigenesis and cance...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Chang Gung University
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283569/ https://www.ncbi.nlm.nih.gov/pubmed/32513392 http://dx.doi.org/10.1016/j.bj.2020.03.001 |
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author | Wu, Kou-Juey |
author_facet | Wu, Kou-Juey |
author_sort | Wu, Kou-Juey |
collection | PubMed |
description | Cancer stemness represents one of the major mechanisms that predispose patients to tumor aggressiveness, metastasis, and treatment resistance. MicroRNA biogenesis is an important process controlling miRNA processing and maturation. Deregulation of miRNA biogenesis can lead to tumorigenesis and cancer stemness. DDX17 is a co-factor of the miRNA microprocessor. Misregulation of DDX17 can be associated with cancer stemness. K63-linked polyubiquitination of DDX17 presents a concerted mechanism of decreased synthesis of stemness-inhibiting miRNAs and increased transcriptional activation of stemness-related gene expression. K63-linked polyubiquitination of HAUSP serves as a scaffold to anchor HIF-1α, CBP, the mediator complex, and the super-elongation complex to enhance HIF-1α-induced gene transcription. Recent progress in RNA modifications shows that RNA N6-methyladenosine (m6A) modification is a crucial mechanism to regulate RNA levels. M6A modification of miRNAs can also be linked to tumorigenesis and cancer stemness. Overall, miRNA biogenesis and K63-linked polyubiquitination of DDX17 play an important role in the induction of cancer stemness. Delineation of the mechanisms and identification of suitable targets may provide new therapeutic options for treatment-resistant cancers. |
format | Online Article Text |
id | pubmed-7283569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Chang Gung University |
record_format | MEDLINE/PubMed |
spelling | pubmed-72835692020-06-15 The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness Wu, Kou-Juey Biomed J Review Article Cancer stemness represents one of the major mechanisms that predispose patients to tumor aggressiveness, metastasis, and treatment resistance. MicroRNA biogenesis is an important process controlling miRNA processing and maturation. Deregulation of miRNA biogenesis can lead to tumorigenesis and cancer stemness. DDX17 is a co-factor of the miRNA microprocessor. Misregulation of DDX17 can be associated with cancer stemness. K63-linked polyubiquitination of DDX17 presents a concerted mechanism of decreased synthesis of stemness-inhibiting miRNAs and increased transcriptional activation of stemness-related gene expression. K63-linked polyubiquitination of HAUSP serves as a scaffold to anchor HIF-1α, CBP, the mediator complex, and the super-elongation complex to enhance HIF-1α-induced gene transcription. Recent progress in RNA modifications shows that RNA N6-methyladenosine (m6A) modification is a crucial mechanism to regulate RNA levels. M6A modification of miRNAs can also be linked to tumorigenesis and cancer stemness. Overall, miRNA biogenesis and K63-linked polyubiquitination of DDX17 play an important role in the induction of cancer stemness. Delineation of the mechanisms and identification of suitable targets may provide new therapeutic options for treatment-resistant cancers. Chang Gung University 2020-04 2020-04-13 /pmc/articles/PMC7283569/ /pubmed/32513392 http://dx.doi.org/10.1016/j.bj.2020.03.001 Text en © 2020 Chang Gung University. Publishing services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Review Article Wu, Kou-Juey The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness |
title | The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness |
title_full | The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness |
title_fullStr | The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness |
title_full_unstemmed | The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness |
title_short | The role of miRNA biogenesis and DDX17 in tumorigenesis and cancer stemness |
title_sort | role of mirna biogenesis and ddx17 in tumorigenesis and cancer stemness |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283569/ https://www.ncbi.nlm.nih.gov/pubmed/32513392 http://dx.doi.org/10.1016/j.bj.2020.03.001 |
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