Optogenetic Manipulation of Postsynaptic cAMP Using a Novel Transgenic Mouse Line Enables Synaptic Plasticity and Enhances Depolarization Following Tetanic Stimulation in the Hippocampal Dentate Gyrus

cAMP is a positive regulator tightly involved in certain types of synaptic plasticity and related memory functions. However, its spatiotemporal roles at the synaptic and neural circuit levels remain elusive. Using a combination of a cAMP optogenetics approach and voltage-sensitive dye (VSD) imaging...

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Detalles Bibliográficos
Autores principales: Luyben, Thomas T., Rai, Jayant, Li, Hang, Georgiou, John, Avila, Ariel, Zhen, Mei, Collingridge, Graham L., Tominaga, Takashi, Okamoto, Kenichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283606/
https://www.ncbi.nlm.nih.gov/pubmed/32581725
http://dx.doi.org/10.3389/fncir.2020.00024

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