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Potential role of platelets in COVID‐19: Implications for thrombosis

For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that...

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Autor principal: Koupenova, Milka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283793/
https://www.ncbi.nlm.nih.gov/pubmed/32685881
http://dx.doi.org/10.1002/rth2.12397
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author Koupenova, Milka
author_facet Koupenova, Milka
author_sort Koupenova, Milka
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description For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during coronavirus disease 2019.
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spelling pubmed-72837932020-06-10 Potential role of platelets in COVID‐19: Implications for thrombosis Koupenova, Milka Res Pract Thromb Haemost Forum For the past 150 years, platelets have been recognized as the major blood component that mediates hemostasis and thrombosis. In more recent years, however, we have come to appreciate that platelets also perform profound immune functions during infection with various pathogens. We now recognize that platelets can also mediate a response to various RNA viruses such as influenza and that many viral infections, including severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), can affect platelet count. Thrombocytopenia and increased coagulation have been independently associated with increased mortality. This article provides a perspective on the potential roles of platelets during coronavirus disease 2019. John Wiley and Sons Inc. 2020-06-21 /pmc/articles/PMC7283793/ /pubmed/32685881 http://dx.doi.org/10.1002/rth2.12397 Text en © 2020 The Authors. Research and Practice in Thrombosis and Haemostasis published by Wiley Periodicals LLC on behalf of International Society on Thrombosis and Haemostasis. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Forum
Koupenova, Milka
Potential role of platelets in COVID‐19: Implications for thrombosis
title Potential role of platelets in COVID‐19: Implications for thrombosis
title_full Potential role of platelets in COVID‐19: Implications for thrombosis
title_fullStr Potential role of platelets in COVID‐19: Implications for thrombosis
title_full_unstemmed Potential role of platelets in COVID‐19: Implications for thrombosis
title_short Potential role of platelets in COVID‐19: Implications for thrombosis
title_sort potential role of platelets in covid‐19: implications for thrombosis
topic Forum
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283793/
https://www.ncbi.nlm.nih.gov/pubmed/32685881
http://dx.doi.org/10.1002/rth2.12397
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