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Epigenetic Marks at the Ribosomal DNA Promoter in Skeletal Muscle Are Negatively Associated With Degree of Impairment in Cerebral Palsy

Introduction: Cerebral palsy (CP) is the most common motor impairment in children. Skeletal muscles in individuals with CP are typically weak, thin, and stiff. Whether epigenetic changes at the ribosomal DNA (rDNA) promoter are involved in this dysregulation remains unknown. Methods: Skeletal muscle...

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Detalles Bibliográficos
Autores principales: von Walden, Ferdinand, Fernandez-Gonzalo, Rodrigo, Pingel, Jessica, McCarthy, John, Stål, Per, Pontén, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283884/
https://www.ncbi.nlm.nih.gov/pubmed/32582584
http://dx.doi.org/10.3389/fped.2020.00236