GSK-3β Contributes to Parkinsonian Dopaminergic Neuron Death: Evidence From Conditional Knockout Mice and Tideglusib

Glycogen synthase kinase-3 (GSK-3) dysregulation has been implicated in nigral dopaminergic neurodegeneration, one of the main pathological features of Parkinson’s disease (PD). The two isoforms, GSK-3α and GSK-3β, have both been suggested to play a detrimental role in neuronal death. To date, sever...

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Detalles Bibliográficos
Autores principales: Li, Junyu, Ma, Shanshan, Chen, Jingnan, Hu, Kunhua, Li, Yongyi, Zhang, Zeyu, Su, Zixiang, Woodgett, James R., Li, Mingtao, Huang, Qiaoying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283909/
https://www.ncbi.nlm.nih.gov/pubmed/32581704
http://dx.doi.org/10.3389/fnmol.2020.00081

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