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Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy

Cytokine-based immunotherapy is a promising field in the cancer treatment, since cytokines, as proteins of the immune system, are able to modulate the host immune response toward cancer cell, as well as directly induce tumor cell death. Since a low dose monotherapy with some cytokines has no signifi...

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Autores principales: Chulpanova, Daria S., Kitaeva, Kristina V., Green, Andrew R., Rizvanov, Albert A., Solovyeva, Valeriya V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283917/
https://www.ncbi.nlm.nih.gov/pubmed/32582698
http://dx.doi.org/10.3389/fcell.2020.00402
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author Chulpanova, Daria S.
Kitaeva, Kristina V.
Green, Andrew R.
Rizvanov, Albert A.
Solovyeva, Valeriya V.
author_facet Chulpanova, Daria S.
Kitaeva, Kristina V.
Green, Andrew R.
Rizvanov, Albert A.
Solovyeva, Valeriya V.
author_sort Chulpanova, Daria S.
collection PubMed
description Cytokine-based immunotherapy is a promising field in the cancer treatment, since cytokines, as proteins of the immune system, are able to modulate the host immune response toward cancer cell, as well as directly induce tumor cell death. Since a low dose monotherapy with some cytokines has no significant therapeutic results and a high dose treatment leads to a number of side effects caused by the pleiotropic effect of cytokines, the problem of understanding the influence of cytokines on the immune cells involved in the pro- and anti-tumor immune response remains a pressing one. Immune system cells carry CD makers on their surface which can be used to identify various populations of cells of the immune system that play different roles in pro- and anti-tumor immune responses. This review discusses the functions and specific CD markers of various immune cell populations which are reported to participate in the regulation of the immune response against the tumor. The results of research studies and clinical trials investigating the effect of cytokine therapy on the regulation of immune cell populations and their surface markers are also discussed. Current trends in the development of cancer immunotherapy, as well as the role of cytokines in combination with other therapeutic agents, are also discussed.
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spelling pubmed-72839172020-06-23 Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy Chulpanova, Daria S. Kitaeva, Kristina V. Green, Andrew R. Rizvanov, Albert A. Solovyeva, Valeriya V. Front Cell Dev Biol Cell and Developmental Biology Cytokine-based immunotherapy is a promising field in the cancer treatment, since cytokines, as proteins of the immune system, are able to modulate the host immune response toward cancer cell, as well as directly induce tumor cell death. Since a low dose monotherapy with some cytokines has no significant therapeutic results and a high dose treatment leads to a number of side effects caused by the pleiotropic effect of cytokines, the problem of understanding the influence of cytokines on the immune cells involved in the pro- and anti-tumor immune response remains a pressing one. Immune system cells carry CD makers on their surface which can be used to identify various populations of cells of the immune system that play different roles in pro- and anti-tumor immune responses. This review discusses the functions and specific CD markers of various immune cell populations which are reported to participate in the regulation of the immune response against the tumor. The results of research studies and clinical trials investigating the effect of cytokine therapy on the regulation of immune cell populations and their surface markers are also discussed. Current trends in the development of cancer immunotherapy, as well as the role of cytokines in combination with other therapeutic agents, are also discussed. Frontiers Media S.A. 2020-06-03 /pmc/articles/PMC7283917/ /pubmed/32582698 http://dx.doi.org/10.3389/fcell.2020.00402 Text en Copyright © 2020 Chulpanova, Kitaeva, Green, Rizvanov and Solovyeva. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Chulpanova, Daria S.
Kitaeva, Kristina V.
Green, Andrew R.
Rizvanov, Albert A.
Solovyeva, Valeriya V.
Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy
title Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy
title_full Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy
title_fullStr Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy
title_full_unstemmed Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy
title_short Molecular Aspects and Future Perspectives of Cytokine-Based Anti-cancer Immunotherapy
title_sort molecular aspects and future perspectives of cytokine-based anti-cancer immunotherapy
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7283917/
https://www.ncbi.nlm.nih.gov/pubmed/32582698
http://dx.doi.org/10.3389/fcell.2020.00402
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