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A polygenic biomarker to identify patients with severe hypercholesterolemia of polygenic origin

BACKGROUND: Severe hypercholesterolemia (HC, LDL‐C > 4.9 mmol/L) affects over 30 million people worldwide. In this study, we validated a new polygenic risk score (PRS) for LDL‐C. METHODS: Summary statistics from the Global Lipid Genome Consortium and genotype data from two large populations were...

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Detalles Bibliográficos
Autores principales:	Leal, Luis G., Hoggart, Clive, Jarvelin, Marjo‐Riitta, Herzig, Karl‐Heinz, Sternberg, Michael J. E., David, Alessia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284038/ https://www.ncbi.nlm.nih.gov/pubmed/32307928 http://dx.doi.org/10.1002/mgg3.1248

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