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Intimate Relations: Molecular and Immunologic Interactions Between Neisseria gonorrhoeae and HIV-1

While the global incidence of human immunodeficiency virus (HIV-1) remains well above UNAIDS targets, sexual transmission HIV is surprisingly inefficient. A variety of host, viral and environmental factors can either increase HIV-1 shedding in the infected partner and/or increase mucosal susceptibil...

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Autores principales: Guvenc, Furkan, Kaul, Rupert, Gray-Owen, Scott D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284112/
https://www.ncbi.nlm.nih.gov/pubmed/32582133
http://dx.doi.org/10.3389/fmicb.2020.01299
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author Guvenc, Furkan
Kaul, Rupert
Gray-Owen, Scott D.
author_facet Guvenc, Furkan
Kaul, Rupert
Gray-Owen, Scott D.
author_sort Guvenc, Furkan
collection PubMed
description While the global incidence of human immunodeficiency virus (HIV-1) remains well above UNAIDS targets, sexual transmission HIV is surprisingly inefficient. A variety of host, viral and environmental factors can either increase HIV-1 shedding in the infected partner and/or increase mucosal susceptibility of the HIV-1 uninfected partner. Clinical and epidemiological studies have clearly established that Neisseria gonorrhoeae substantially enhances HIV-1 transmission, despite it not being an ulcerative infection. This review will consider findings from molecular, immunologic and clinical studies that have focused on each of these two human-restricted pathogens, in order to develop an integrative model that describes how gonococci can both increase mucosal shedding of HIV-1 from a co-infected person and facilitate virus establishment in a susceptible host.
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spelling pubmed-72841122020-06-23 Intimate Relations: Molecular and Immunologic Interactions Between Neisseria gonorrhoeae and HIV-1 Guvenc, Furkan Kaul, Rupert Gray-Owen, Scott D. Front Microbiol Microbiology While the global incidence of human immunodeficiency virus (HIV-1) remains well above UNAIDS targets, sexual transmission HIV is surprisingly inefficient. A variety of host, viral and environmental factors can either increase HIV-1 shedding in the infected partner and/or increase mucosal susceptibility of the HIV-1 uninfected partner. Clinical and epidemiological studies have clearly established that Neisseria gonorrhoeae substantially enhances HIV-1 transmission, despite it not being an ulcerative infection. This review will consider findings from molecular, immunologic and clinical studies that have focused on each of these two human-restricted pathogens, in order to develop an integrative model that describes how gonococci can both increase mucosal shedding of HIV-1 from a co-infected person and facilitate virus establishment in a susceptible host. Frontiers Media S.A. 2020-06-03 /pmc/articles/PMC7284112/ /pubmed/32582133 http://dx.doi.org/10.3389/fmicb.2020.01299 Text en Copyright © 2020 Guvenc, Kaul and Gray-Owen. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Guvenc, Furkan
Kaul, Rupert
Gray-Owen, Scott D.
Intimate Relations: Molecular and Immunologic Interactions Between Neisseria gonorrhoeae and HIV-1
title Intimate Relations: Molecular and Immunologic Interactions Between Neisseria gonorrhoeae and HIV-1
title_full Intimate Relations: Molecular and Immunologic Interactions Between Neisseria gonorrhoeae and HIV-1
title_fullStr Intimate Relations: Molecular and Immunologic Interactions Between Neisseria gonorrhoeae and HIV-1
title_full_unstemmed Intimate Relations: Molecular and Immunologic Interactions Between Neisseria gonorrhoeae and HIV-1
title_short Intimate Relations: Molecular and Immunologic Interactions Between Neisseria gonorrhoeae and HIV-1
title_sort intimate relations: molecular and immunologic interactions between neisseria gonorrhoeae and hiv-1
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284112/
https://www.ncbi.nlm.nih.gov/pubmed/32582133
http://dx.doi.org/10.3389/fmicb.2020.01299
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