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Identification and analysis of novel small molecule inhibitors of RNase E: Implications for antibacterial targeting and regulation of RNase E
Increasing resistance of bacteria to antibiotics is a serious global challenge and there is a need to unlock the potential of novel antibacterial targets. One such target is the essential prokaryotic endoribonuclease RNase E. Using a combination of in silico high-throughput screening and in vitro va...
Autores principales: | Mardle, Charlotte E., Goddard, Layla R., Spelman, Bailei C., Atkins, Helen S., Butt, Louise E., Cox, Paul A., Gowers, Darren M., Vincent, Helen A., Callaghan, Anastasia J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284133/ https://www.ncbi.nlm.nih.gov/pubmed/32548313 http://dx.doi.org/10.1016/j.bbrep.2020.100773 |
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