Cargando…

The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction

Metabolic syndrome (MetS) represents a set of clinical findings that include visceral adiposity, insulin-resistance, high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C) levels and hypertension, which is linked to an increased risk of developing type 2 diabetes mellitus (T2DM) a...

Descripción completa

Detalles Bibliográficos
Autores principales: Carresi, Cristina, Gliozzi, Micaela, Musolino, Vincenzo, Scicchitano, Miriam, Scarano, Federica, Bosco, Francesca, Nucera, Saverio, Maiuolo, Jessica, Macrì, Roberta, Ruga, Stefano, Oppedisano, Francesca, Zito, Maria Caterina, Guarnieri, Lorenza, Mollace, Rocco, Tavernese, Annamaria, Palma, Ernesto, Bombardelli, Ezio, Fini, Massimo, Mollace, Vincenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284500/
https://www.ncbi.nlm.nih.gov/pubmed/32455840
http://dx.doi.org/10.3390/nu12051504
_version_ 1783544481541259264
author Carresi, Cristina
Gliozzi, Micaela
Musolino, Vincenzo
Scicchitano, Miriam
Scarano, Federica
Bosco, Francesca
Nucera, Saverio
Maiuolo, Jessica
Macrì, Roberta
Ruga, Stefano
Oppedisano, Francesca
Zito, Maria Caterina
Guarnieri, Lorenza
Mollace, Rocco
Tavernese, Annamaria
Palma, Ernesto
Bombardelli, Ezio
Fini, Massimo
Mollace, Vincenzo
author_facet Carresi, Cristina
Gliozzi, Micaela
Musolino, Vincenzo
Scicchitano, Miriam
Scarano, Federica
Bosco, Francesca
Nucera, Saverio
Maiuolo, Jessica
Macrì, Roberta
Ruga, Stefano
Oppedisano, Francesca
Zito, Maria Caterina
Guarnieri, Lorenza
Mollace, Rocco
Tavernese, Annamaria
Palma, Ernesto
Bombardelli, Ezio
Fini, Massimo
Mollace, Vincenzo
author_sort Carresi, Cristina
collection PubMed
description Metabolic syndrome (MetS) represents a set of clinical findings that include visceral adiposity, insulin-resistance, high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C) levels and hypertension, which is linked to an increased risk of developing type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The pathogenesis of MetS involves both genetic and acquired factors triggering oxidative stress, cellular dysfunction and systemic inflammation process mainly responsible for the pathophysiological mechanism. In recent years, MetS has gained importance due to the exponential increase in obesity worldwide. However, at present, it remains underdiagnosed and undertreated. The present review will summarize the pathogenesis of MetS and the existing pharmacological therapies currently used and focus attention on the beneficial effects of natural compounds to reduce the risk and progression of MetS. In this regard, emerging evidence suggests a potential protective role of bergamot extracts, in particular bergamot flavonoids, in the management of different features of MetS, due to their pleiotropic anti-oxidative, anti-inflammatory and lipid-lowering effects.
format Online
Article
Text
id pubmed-7284500
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72845002020-06-19 The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction Carresi, Cristina Gliozzi, Micaela Musolino, Vincenzo Scicchitano, Miriam Scarano, Federica Bosco, Francesca Nucera, Saverio Maiuolo, Jessica Macrì, Roberta Ruga, Stefano Oppedisano, Francesca Zito, Maria Caterina Guarnieri, Lorenza Mollace, Rocco Tavernese, Annamaria Palma, Ernesto Bombardelli, Ezio Fini, Massimo Mollace, Vincenzo Nutrients Review Metabolic syndrome (MetS) represents a set of clinical findings that include visceral adiposity, insulin-resistance, high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C) levels and hypertension, which is linked to an increased risk of developing type 2 diabetes mellitus (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The pathogenesis of MetS involves both genetic and acquired factors triggering oxidative stress, cellular dysfunction and systemic inflammation process mainly responsible for the pathophysiological mechanism. In recent years, MetS has gained importance due to the exponential increase in obesity worldwide. However, at present, it remains underdiagnosed and undertreated. The present review will summarize the pathogenesis of MetS and the existing pharmacological therapies currently used and focus attention on the beneficial effects of natural compounds to reduce the risk and progression of MetS. In this regard, emerging evidence suggests a potential protective role of bergamot extracts, in particular bergamot flavonoids, in the management of different features of MetS, due to their pleiotropic anti-oxidative, anti-inflammatory and lipid-lowering effects. MDPI 2020-05-21 /pmc/articles/PMC7284500/ /pubmed/32455840 http://dx.doi.org/10.3390/nu12051504 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Carresi, Cristina
Gliozzi, Micaela
Musolino, Vincenzo
Scicchitano, Miriam
Scarano, Federica
Bosco, Francesca
Nucera, Saverio
Maiuolo, Jessica
Macrì, Roberta
Ruga, Stefano
Oppedisano, Francesca
Zito, Maria Caterina
Guarnieri, Lorenza
Mollace, Rocco
Tavernese, Annamaria
Palma, Ernesto
Bombardelli, Ezio
Fini, Massimo
Mollace, Vincenzo
The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction
title The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction
title_full The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction
title_fullStr The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction
title_full_unstemmed The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction
title_short The Effect of Natural Antioxidants in the Development of Metabolic Syndrome: Focus on Bergamot Polyphenolic Fraction
title_sort effect of natural antioxidants in the development of metabolic syndrome: focus on bergamot polyphenolic fraction
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284500/
https://www.ncbi.nlm.nih.gov/pubmed/32455840
http://dx.doi.org/10.3390/nu12051504
work_keys_str_mv AT carresicristina theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT gliozzimicaela theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT musolinovincenzo theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT scicchitanomiriam theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT scaranofederica theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT boscofrancesca theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT nucerasaverio theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT maiuolojessica theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT macriroberta theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT rugastefano theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT oppedisanofrancesca theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT zitomariacaterina theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT guarnierilorenza theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT mollacerocco theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT taverneseannamaria theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT palmaernesto theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT bombardelliezio theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT finimassimo theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT mollacevincenzo theeffectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT carresicristina effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT gliozzimicaela effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT musolinovincenzo effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT scicchitanomiriam effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT scaranofederica effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT boscofrancesca effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT nucerasaverio effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT maiuolojessica effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT macriroberta effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT rugastefano effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT oppedisanofrancesca effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT zitomariacaterina effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT guarnierilorenza effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT mollacerocco effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT taverneseannamaria effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT palmaernesto effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT bombardelliezio effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT finimassimo effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction
AT mollacevincenzo effectofnaturalantioxidantsinthedevelopmentofmetabolicsyndromefocusonbergamotpolyphenolicfraction