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Characterization of the Blood–Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma

The blood–brain barrier (BBB) hinders the brain delivery of many anticancer drugs. In pediatric patients, diffuse intrinsic pontine glioma (DIPG) represents the main cause of brain cancer mortality lacking effective drug therapy. Using sham and DIPG-bearing rats, we analyzed (1) the brain distributi...

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Detalles Bibliográficos
Autores principales:	Chaves, Catarina, Declèves, Xavier, Taghi, Meryam, Menet, Marie-Claude, Lacombe, Joelle, Varlet, Pascale, Olaciregui, Nagore G., Carcaboso, Angel M., Cisternino, Salvatore
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284501/ https://www.ncbi.nlm.nih.gov/pubmed/32349240 http://dx.doi.org/10.3390/pharmaceutics12050399

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