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Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial

Lifestyle modification is an important component of essential hypertension (EH) therapy. The aim of the Hypertension Intensive Nutrition Treatment (HINTreat) parallel, randomized controlled trial was to examine the effect of a 6-month intensive lifestyle treatment (ILT) (diet plus exercise with mont...

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Autores principales: Vamvakis, Anastasios, Gkaliagkousi, Eugenia, Lazaridis, Antonios, Grammatikopoulou, Maria G., Triantafyllou, Areti, Nikolaidou, Barbara, Koletsos, Nikolaos, Anyfanti, Panagiota, Tzimos, Christos, Zebekakis, Pantelis, Douma, Stella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284619/
https://www.ncbi.nlm.nih.gov/pubmed/32392715
http://dx.doi.org/10.3390/nu12051326
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author Vamvakis, Anastasios
Gkaliagkousi, Eugenia
Lazaridis, Antonios
Grammatikopoulou, Maria G.
Triantafyllou, Areti
Nikolaidou, Barbara
Koletsos, Nikolaos
Anyfanti, Panagiota
Tzimos, Christos
Zebekakis, Pantelis
Douma, Stella
author_facet Vamvakis, Anastasios
Gkaliagkousi, Eugenia
Lazaridis, Antonios
Grammatikopoulou, Maria G.
Triantafyllou, Areti
Nikolaidou, Barbara
Koletsos, Nikolaos
Anyfanti, Panagiota
Tzimos, Christos
Zebekakis, Pantelis
Douma, Stella
author_sort Vamvakis, Anastasios
collection PubMed
description Lifestyle modification is an important component of essential hypertension (EH) therapy. The aim of the Hypertension Intensive Nutrition Treatment (HINTreat) parallel, randomized controlled trial was to examine the effect of a 6-month intensive lifestyle treatment (ILT) (diet plus exercise with monthly visits) compared to the usual care. A total of 76 adults with stage 1 EH were randomized (38 in each group). Dietary analysis, anthropometry, physical activity, biochemical and urine profile, blood pressure (BP), asymmetric dimethylarginine (ADMA), central hemodynamics, β-stiffness index and carotid intima media-thickness were evaluated. The dietary inflammatory index (DII) was calculated for each participant from the intake of 29 nutrients/food components. At the end of the trial, participants in the ILT group reduced their 24h urinary Na excretion (p ≤ 0.001), daytime systolic BP (p ≤ 0.048) and mean carotid β-stiffness index (p ≤ 0.005) and ameliorated their lipidemic profile compared to the standard care. Univariate analysis for the total sample showed a strong association between DII and ADMA levels (β = 0.089, p ≤ 0.01). ILT is effective in improving the inflammatory components of the diet and selected cardiometabolic parameters, including arterial stiffness.
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spelling pubmed-72846192020-06-19 Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial Vamvakis, Anastasios Gkaliagkousi, Eugenia Lazaridis, Antonios Grammatikopoulou, Maria G. Triantafyllou, Areti Nikolaidou, Barbara Koletsos, Nikolaos Anyfanti, Panagiota Tzimos, Christos Zebekakis, Pantelis Douma, Stella Nutrients Article Lifestyle modification is an important component of essential hypertension (EH) therapy. The aim of the Hypertension Intensive Nutrition Treatment (HINTreat) parallel, randomized controlled trial was to examine the effect of a 6-month intensive lifestyle treatment (ILT) (diet plus exercise with monthly visits) compared to the usual care. A total of 76 adults with stage 1 EH were randomized (38 in each group). Dietary analysis, anthropometry, physical activity, biochemical and urine profile, blood pressure (BP), asymmetric dimethylarginine (ADMA), central hemodynamics, β-stiffness index and carotid intima media-thickness were evaluated. The dietary inflammatory index (DII) was calculated for each participant from the intake of 29 nutrients/food components. At the end of the trial, participants in the ILT group reduced their 24h urinary Na excretion (p ≤ 0.001), daytime systolic BP (p ≤ 0.048) and mean carotid β-stiffness index (p ≤ 0.005) and ameliorated their lipidemic profile compared to the standard care. Univariate analysis for the total sample showed a strong association between DII and ADMA levels (β = 0.089, p ≤ 0.01). ILT is effective in improving the inflammatory components of the diet and selected cardiometabolic parameters, including arterial stiffness. MDPI 2020-05-07 /pmc/articles/PMC7284619/ /pubmed/32392715 http://dx.doi.org/10.3390/nu12051326 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vamvakis, Anastasios
Gkaliagkousi, Eugenia
Lazaridis, Antonios
Grammatikopoulou, Maria G.
Triantafyllou, Areti
Nikolaidou, Barbara
Koletsos, Nikolaos
Anyfanti, Panagiota
Tzimos, Christos
Zebekakis, Pantelis
Douma, Stella
Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial
title Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial
title_full Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial
title_fullStr Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial
title_full_unstemmed Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial
title_short Impact of Intensive Lifestyle Treatment (Diet Plus Exercise) on Endothelial and Vascular Function, Arterial Stiffness and Blood Pressure in Stage 1 Hypertension: Results of the HINTreat Randomized Controlled Trial
title_sort impact of intensive lifestyle treatment (diet plus exercise) on endothelial and vascular function, arterial stiffness and blood pressure in stage 1 hypertension: results of the hintreat randomized controlled trial
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284619/
https://www.ncbi.nlm.nih.gov/pubmed/32392715
http://dx.doi.org/10.3390/nu12051326
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