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Metabolites, Nutrients, and Lifestyle Factors in Relation to Coffee Consumption: An Environment-Wide Association Study

Coffee consumption has been inversely associated with various diseases; however, the underlying mechanisms are not entirely clear. We used data of 17,752 Third National Health and Nutrition Examination Survey participants to investigate the association of 245 metabolites, nutrients, and lifestyle fa...

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Autores principales: Elhadad, Mohamed A., Karavasiloglou, Nena, Wulaningsih, Wahyu, Tsilidis, Konstantinos K, Tzoulaki, Ioanna, Patel, Chirag J, Rohrmann, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284649/
https://www.ncbi.nlm.nih.gov/pubmed/32438643
http://dx.doi.org/10.3390/nu12051470
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author Elhadad, Mohamed A.
Karavasiloglou, Nena
Wulaningsih, Wahyu
Tsilidis, Konstantinos K
Tzoulaki, Ioanna
Patel, Chirag J
Rohrmann, Sabine
author_facet Elhadad, Mohamed A.
Karavasiloglou, Nena
Wulaningsih, Wahyu
Tsilidis, Konstantinos K
Tzoulaki, Ioanna
Patel, Chirag J
Rohrmann, Sabine
author_sort Elhadad, Mohamed A.
collection PubMed
description Coffee consumption has been inversely associated with various diseases; however, the underlying mechanisms are not entirely clear. We used data of 17,752 Third National Health and Nutrition Examination Survey participants to investigate the association of 245 metabolites, nutrients, and lifestyle factors with coffee consumption. We used data from the first phase (n = 8825) to identify factors with a false discovery rate of <5%. We then replicated our results using data from the second phase (n = 8927). Regular coffee consumption was positively associated with active and passive smoking, serum lead and urinary cadmium concentrations, dietary intake of potassium and magnesium, and aspirin intake. In contrast, regular coffee consumption was inversely associated with serum folate and red blood cell folate levels, serum vitamin E and C, and beta-cryptoxanthin concentrations, Healthy Eating Index score, and total serum bilirubin. Most of the aforementioned associations were also observed for caffeinated beverage intake. In our assessment of the association between coffee consumption and selected metabolites, nutrients, and lifestyle factors, we observed that regular coffee and caffeinated beverage consumption was strongly associated with smoking, serum lead levels, and poorer dietary habits.
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spelling pubmed-72846492020-06-15 Metabolites, Nutrients, and Lifestyle Factors in Relation to Coffee Consumption: An Environment-Wide Association Study Elhadad, Mohamed A. Karavasiloglou, Nena Wulaningsih, Wahyu Tsilidis, Konstantinos K Tzoulaki, Ioanna Patel, Chirag J Rohrmann, Sabine Nutrients Article Coffee consumption has been inversely associated with various diseases; however, the underlying mechanisms are not entirely clear. We used data of 17,752 Third National Health and Nutrition Examination Survey participants to investigate the association of 245 metabolites, nutrients, and lifestyle factors with coffee consumption. We used data from the first phase (n = 8825) to identify factors with a false discovery rate of <5%. We then replicated our results using data from the second phase (n = 8927). Regular coffee consumption was positively associated with active and passive smoking, serum lead and urinary cadmium concentrations, dietary intake of potassium and magnesium, and aspirin intake. In contrast, regular coffee consumption was inversely associated with serum folate and red blood cell folate levels, serum vitamin E and C, and beta-cryptoxanthin concentrations, Healthy Eating Index score, and total serum bilirubin. Most of the aforementioned associations were also observed for caffeinated beverage intake. In our assessment of the association between coffee consumption and selected metabolites, nutrients, and lifestyle factors, we observed that regular coffee and caffeinated beverage consumption was strongly associated with smoking, serum lead levels, and poorer dietary habits. MDPI 2020-05-19 /pmc/articles/PMC7284649/ /pubmed/32438643 http://dx.doi.org/10.3390/nu12051470 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Elhadad, Mohamed A.
Karavasiloglou, Nena
Wulaningsih, Wahyu
Tsilidis, Konstantinos K
Tzoulaki, Ioanna
Patel, Chirag J
Rohrmann, Sabine
Metabolites, Nutrients, and Lifestyle Factors in Relation to Coffee Consumption: An Environment-Wide Association Study
title Metabolites, Nutrients, and Lifestyle Factors in Relation to Coffee Consumption: An Environment-Wide Association Study
title_full Metabolites, Nutrients, and Lifestyle Factors in Relation to Coffee Consumption: An Environment-Wide Association Study
title_fullStr Metabolites, Nutrients, and Lifestyle Factors in Relation to Coffee Consumption: An Environment-Wide Association Study
title_full_unstemmed Metabolites, Nutrients, and Lifestyle Factors in Relation to Coffee Consumption: An Environment-Wide Association Study
title_short Metabolites, Nutrients, and Lifestyle Factors in Relation to Coffee Consumption: An Environment-Wide Association Study
title_sort metabolites, nutrients, and lifestyle factors in relation to coffee consumption: an environment-wide association study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284649/
https://www.ncbi.nlm.nih.gov/pubmed/32438643
http://dx.doi.org/10.3390/nu12051470
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