Enhancement of the Physical Stability of Amorphous Sildenafil in a Binary Mixture, with either a Plasticizing or Antiplasticizing Compound

The main purpose of this paper was to evaluate the impact of both high- and low-T(g) polymer additives on the physical stability of an amorphous drug, sildenafil (SIL). The molecular mobility of neat amorphous SIL was strongly affected by the polymeric excipients used (Kollidon VA64 (KVA) and poly(v...

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Detalles Bibliográficos
Autores principales: Knapik-Kowalczuk, Justyna, Chmiel, Krzysztof, Pacułt, Justyna, Bialek, Klaudia, Tajber, Lidia, Paluch, Marian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284710/
https://www.ncbi.nlm.nih.gov/pubmed/32443637
http://dx.doi.org/10.3390/pharmaceutics12050460

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284710/
https://www.ncbi.nlm.nih.gov/pubmed/32443637
http://dx.doi.org/10.3390/pharmaceutics12050460

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