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Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer
A ketogenic diet is expected to be an effective support therapy for patients with cancer, but the degree and duration of carbohydrate restriction are unclear. We performed a case series study of a new ketogenic diet regimen in patients with different types of stage IV cancer. Carbohydrates were rest...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284721/ https://www.ncbi.nlm.nih.gov/pubmed/32438645 http://dx.doi.org/10.3390/nu12051473 |
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author | Hagihara, Keisuke Kajimoto, Katsufumi Osaga, Satoshi Nagai, Naoko Shimosegawa, Eku Nakata, Hideyuki Saito, Hitomi Nakano, Mai Takeuchi, Mariko Kanki, Hideaki Kagitani-Shimono, Kuriko Kijima, Takashi |
author_facet | Hagihara, Keisuke Kajimoto, Katsufumi Osaga, Satoshi Nagai, Naoko Shimosegawa, Eku Nakata, Hideyuki Saito, Hitomi Nakano, Mai Takeuchi, Mariko Kanki, Hideaki Kagitani-Shimono, Kuriko Kijima, Takashi |
author_sort | Hagihara, Keisuke |
collection | PubMed |
description | A ketogenic diet is expected to be an effective support therapy for patients with cancer, but the degree and duration of carbohydrate restriction are unclear. We performed a case series study of a new ketogenic diet regimen in patients with different types of stage IV cancer. Carbohydrates were restricted to 10 g/day during week one, 20 g/day from week two for three months, and 30 g/day thereafter. A total of 55 patients participated in the study, and data from 37 patients administered the ketogenic diet for three months were analyzed. No severe adverse events associated with the diet were observed. Total ketone bodies increased significantly, and both fasting blood sugar and insulin levels were suppressed significantly for three months after completion of the study. Five patients showed a partial response on Positron emission tomography–computed tomography (PET-CT) at three months. Three and seven patients showed complete and partial responses, respectively at one year. Median survival was 32.2 (maximum: 80.1) months, and the three-year survival rate was 44.5%. After three months on the ketogenic diet, the serum Alb, BS, and CRP (ABC) score could be used to stratify the patients into groups with significantly different survival rates (p < 0.001, log-rank test). Our ketogenic diet regimen is considered to be a promising support therapy for patients with different types of advanced cancer. |
format | Online Article Text |
id | pubmed-7284721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72847212020-06-15 Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer Hagihara, Keisuke Kajimoto, Katsufumi Osaga, Satoshi Nagai, Naoko Shimosegawa, Eku Nakata, Hideyuki Saito, Hitomi Nakano, Mai Takeuchi, Mariko Kanki, Hideaki Kagitani-Shimono, Kuriko Kijima, Takashi Nutrients Article A ketogenic diet is expected to be an effective support therapy for patients with cancer, but the degree and duration of carbohydrate restriction are unclear. We performed a case series study of a new ketogenic diet regimen in patients with different types of stage IV cancer. Carbohydrates were restricted to 10 g/day during week one, 20 g/day from week two for three months, and 30 g/day thereafter. A total of 55 patients participated in the study, and data from 37 patients administered the ketogenic diet for three months were analyzed. No severe adverse events associated with the diet were observed. Total ketone bodies increased significantly, and both fasting blood sugar and insulin levels were suppressed significantly for three months after completion of the study. Five patients showed a partial response on Positron emission tomography–computed tomography (PET-CT) at three months. Three and seven patients showed complete and partial responses, respectively at one year. Median survival was 32.2 (maximum: 80.1) months, and the three-year survival rate was 44.5%. After three months on the ketogenic diet, the serum Alb, BS, and CRP (ABC) score could be used to stratify the patients into groups with significantly different survival rates (p < 0.001, log-rank test). Our ketogenic diet regimen is considered to be a promising support therapy for patients with different types of advanced cancer. MDPI 2020-05-19 /pmc/articles/PMC7284721/ /pubmed/32438645 http://dx.doi.org/10.3390/nu12051473 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hagihara, Keisuke Kajimoto, Katsufumi Osaga, Satoshi Nagai, Naoko Shimosegawa, Eku Nakata, Hideyuki Saito, Hitomi Nakano, Mai Takeuchi, Mariko Kanki, Hideaki Kagitani-Shimono, Kuriko Kijima, Takashi Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer |
title | Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer |
title_full | Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer |
title_fullStr | Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer |
title_full_unstemmed | Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer |
title_short | Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer |
title_sort | promising effect of a new ketogenic diet regimen in patients with advanced cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284721/ https://www.ncbi.nlm.nih.gov/pubmed/32438645 http://dx.doi.org/10.3390/nu12051473 |
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