Magnetotactic Bacteria and Magnetosomes as Smart Drug Delivery Systems: A New Weapon on the Battlefield with Cancer?

An important direction of research in increasing the effectiveness of cancer therapies is the design of effective drug distribution systems in the body. The development of the new strategies is primarily aimed at improving the stability of the drug after administration and increasing the precision o...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuzajewska, Danuta, Wszołek, Agata, Żwierełło, Wojciech, Kirczuk, Lucyna, Maruszewska, Agnieszka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284773/
https://www.ncbi.nlm.nih.gov/pubmed/32438567
http://dx.doi.org/10.3390/biology9050102
_version_ 1783544546261467136
author Kuzajewska, Danuta
Wszołek, Agata
Żwierełło, Wojciech
Kirczuk, Lucyna
Maruszewska, Agnieszka
author_facet Kuzajewska, Danuta
Wszołek, Agata
Żwierełło, Wojciech
Kirczuk, Lucyna
Maruszewska, Agnieszka
author_sort Kuzajewska, Danuta
collection PubMed
description An important direction of research in increasing the effectiveness of cancer therapies is the design of effective drug distribution systems in the body. The development of the new strategies is primarily aimed at improving the stability of the drug after administration and increasing the precision of drug delivery to the destination. Due to the characteristic features of cancer cells, distributing chemotherapeutics exactly to the microenvironment of the tumor while sparing the healthy tissues is an important issue here. One of the promising solutions that would meet the above requirements is the use of Magnetotactic bacteria (MTBs) and their organelles, called magnetosomes (BMs). MTBs are commonly found in water reservoirs, and BMs that contain ferromagnetic crystals condition the magnetotaxis of these microorganisms. The presented work is a review of the current state of knowledge on the potential use of MTBs and BMs as nanocarriers in the therapy of cancer. The growing amount of literature data indicates that MTBs and BMs may be used as natural nanocarriers for chemotherapeutics, such as classic anti-cancer drugs, antibodies, vaccine DNA, and siRNA. Their use as transporters increases the stability of chemotherapeutics and allows the transfer of individual ligands or their combinations precisely to cancerous tumors, which, in turn, enables the drugs to reach molecular targets more effectively.
format Online
Article
Text
id pubmed-7284773
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-72847732020-06-15 Magnetotactic Bacteria and Magnetosomes as Smart Drug Delivery Systems: A New Weapon on the Battlefield with Cancer? Kuzajewska, Danuta Wszołek, Agata Żwierełło, Wojciech Kirczuk, Lucyna Maruszewska, Agnieszka Biology (Basel) Review An important direction of research in increasing the effectiveness of cancer therapies is the design of effective drug distribution systems in the body. The development of the new strategies is primarily aimed at improving the stability of the drug after administration and increasing the precision of drug delivery to the destination. Due to the characteristic features of cancer cells, distributing chemotherapeutics exactly to the microenvironment of the tumor while sparing the healthy tissues is an important issue here. One of the promising solutions that would meet the above requirements is the use of Magnetotactic bacteria (MTBs) and their organelles, called magnetosomes (BMs). MTBs are commonly found in water reservoirs, and BMs that contain ferromagnetic crystals condition the magnetotaxis of these microorganisms. The presented work is a review of the current state of knowledge on the potential use of MTBs and BMs as nanocarriers in the therapy of cancer. The growing amount of literature data indicates that MTBs and BMs may be used as natural nanocarriers for chemotherapeutics, such as classic anti-cancer drugs, antibodies, vaccine DNA, and siRNA. Their use as transporters increases the stability of chemotherapeutics and allows the transfer of individual ligands or their combinations precisely to cancerous tumors, which, in turn, enables the drugs to reach molecular targets more effectively. MDPI 2020-05-19 /pmc/articles/PMC7284773/ /pubmed/32438567 http://dx.doi.org/10.3390/biology9050102 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Kuzajewska, Danuta
Wszołek, Agata
Żwierełło, Wojciech
Kirczuk, Lucyna
Maruszewska, Agnieszka
Magnetotactic Bacteria and Magnetosomes as Smart Drug Delivery Systems: A New Weapon on the Battlefield with Cancer?
title Magnetotactic Bacteria and Magnetosomes as Smart Drug Delivery Systems: A New Weapon on the Battlefield with Cancer?
title_full Magnetotactic Bacteria and Magnetosomes as Smart Drug Delivery Systems: A New Weapon on the Battlefield with Cancer?
title_fullStr Magnetotactic Bacteria and Magnetosomes as Smart Drug Delivery Systems: A New Weapon on the Battlefield with Cancer?
title_full_unstemmed Magnetotactic Bacteria and Magnetosomes as Smart Drug Delivery Systems: A New Weapon on the Battlefield with Cancer?
title_short Magnetotactic Bacteria and Magnetosomes as Smart Drug Delivery Systems: A New Weapon on the Battlefield with Cancer?
title_sort magnetotactic bacteria and magnetosomes as smart drug delivery systems: a new weapon on the battlefield with cancer?
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284773/
https://www.ncbi.nlm.nih.gov/pubmed/32438567
http://dx.doi.org/10.3390/biology9050102
work_keys_str_mv AT kuzajewskadanuta magnetotacticbacteriaandmagnetosomesassmartdrugdeliverysystemsanewweapononthebattlefieldwithcancer
AT wszołekagata magnetotacticbacteriaandmagnetosomesassmartdrugdeliverysystemsanewweapononthebattlefieldwithcancer
AT zwierełłowojciech magnetotacticbacteriaandmagnetosomesassmartdrugdeliverysystemsanewweapononthebattlefieldwithcancer
AT kirczuklucyna magnetotacticbacteriaandmagnetosomesassmartdrugdeliverysystemsanewweapononthebattlefieldwithcancer
AT maruszewskaagnieszka magnetotacticbacteriaandmagnetosomesassmartdrugdeliverysystemsanewweapononthebattlefieldwithcancer