Cargando…
Effects of Magnesium Oxide (MgO) Shapes on In Vitro and In Vivo Degradation Behaviors of PLA/MgO Composites in Long Term
Biodegradable devices for medical applications should be with an appropriate degradation rate for satisfying the various requirements of bone healing. In this study, composite materials of polylactic acid (PLA)/stearic acid-modified magnesium oxide (MgO) with a 1 wt% were prepared through blending e...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284841/ https://www.ncbi.nlm.nih.gov/pubmed/32397097 http://dx.doi.org/10.3390/polym12051074 |
_version_ | 1783544562614009856 |
---|---|
author | Zhao, Yun Liang, Hui Zhang, Shiqiang Qu, Shengwei Jiang, Yue Chen, Minfang |
author_facet | Zhao, Yun Liang, Hui Zhang, Shiqiang Qu, Shengwei Jiang, Yue Chen, Minfang |
author_sort | Zhao, Yun |
collection | PubMed |
description | Biodegradable devices for medical applications should be with an appropriate degradation rate for satisfying the various requirements of bone healing. In this study, composite materials of polylactic acid (PLA)/stearic acid-modified magnesium oxide (MgO) with a 1 wt% were prepared through blending extrusion, and the effects of the MgO shapes on the composites’ properties in in vitro and in vivo degradation were investigated. The results showed that the long-term degradation behaviors of the composite samples depended significantly on the filler shape. The degradation of the composites is accelerated by the increase in the water uptake rate of the PLA matrix and the composite containing the MgO nanoparticles was influenced more severely by the enhanced hydrophilicity. Furthermore, the pH value of the phosphate buffer solution (PBS) was obviously regulated by the dissolution of MgO through the neutralization of the acidic product of the PLA degradation. In addition, the improvement of the in vivo degrading process of the composite illustrated that the PLA/MgO materials can effectively regulate the degradation of the PLA matrix as well as raise its bioactivity, indicating the composites for utilization as a biomedical material matching the different requirements for bone-related repair. |
format | Online Article Text |
id | pubmed-7284841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72848412020-06-15 Effects of Magnesium Oxide (MgO) Shapes on In Vitro and In Vivo Degradation Behaviors of PLA/MgO Composites in Long Term Zhao, Yun Liang, Hui Zhang, Shiqiang Qu, Shengwei Jiang, Yue Chen, Minfang Polymers (Basel) Article Biodegradable devices for medical applications should be with an appropriate degradation rate for satisfying the various requirements of bone healing. In this study, composite materials of polylactic acid (PLA)/stearic acid-modified magnesium oxide (MgO) with a 1 wt% were prepared through blending extrusion, and the effects of the MgO shapes on the composites’ properties in in vitro and in vivo degradation were investigated. The results showed that the long-term degradation behaviors of the composite samples depended significantly on the filler shape. The degradation of the composites is accelerated by the increase in the water uptake rate of the PLA matrix and the composite containing the MgO nanoparticles was influenced more severely by the enhanced hydrophilicity. Furthermore, the pH value of the phosphate buffer solution (PBS) was obviously regulated by the dissolution of MgO through the neutralization of the acidic product of the PLA degradation. In addition, the improvement of the in vivo degrading process of the composite illustrated that the PLA/MgO materials can effectively regulate the degradation of the PLA matrix as well as raise its bioactivity, indicating the composites for utilization as a biomedical material matching the different requirements for bone-related repair. MDPI 2020-05-08 /pmc/articles/PMC7284841/ /pubmed/32397097 http://dx.doi.org/10.3390/polym12051074 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Zhao, Yun Liang, Hui Zhang, Shiqiang Qu, Shengwei Jiang, Yue Chen, Minfang Effects of Magnesium Oxide (MgO) Shapes on In Vitro and In Vivo Degradation Behaviors of PLA/MgO Composites in Long Term |
title | Effects of Magnesium Oxide (MgO) Shapes on In Vitro and In Vivo Degradation Behaviors of PLA/MgO Composites in Long Term |
title_full | Effects of Magnesium Oxide (MgO) Shapes on In Vitro and In Vivo Degradation Behaviors of PLA/MgO Composites in Long Term |
title_fullStr | Effects of Magnesium Oxide (MgO) Shapes on In Vitro and In Vivo Degradation Behaviors of PLA/MgO Composites in Long Term |
title_full_unstemmed | Effects of Magnesium Oxide (MgO) Shapes on In Vitro and In Vivo Degradation Behaviors of PLA/MgO Composites in Long Term |
title_short | Effects of Magnesium Oxide (MgO) Shapes on In Vitro and In Vivo Degradation Behaviors of PLA/MgO Composites in Long Term |
title_sort | effects of magnesium oxide (mgo) shapes on in vitro and in vivo degradation behaviors of pla/mgo composites in long term |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284841/ https://www.ncbi.nlm.nih.gov/pubmed/32397097 http://dx.doi.org/10.3390/polym12051074 |
work_keys_str_mv | AT zhaoyun effectsofmagnesiumoxidemgoshapesoninvitroandinvivodegradationbehaviorsofplamgocompositesinlongterm AT lianghui effectsofmagnesiumoxidemgoshapesoninvitroandinvivodegradationbehaviorsofplamgocompositesinlongterm AT zhangshiqiang effectsofmagnesiumoxidemgoshapesoninvitroandinvivodegradationbehaviorsofplamgocompositesinlongterm AT qushengwei effectsofmagnesiumoxidemgoshapesoninvitroandinvivodegradationbehaviorsofplamgocompositesinlongterm AT jiangyue effectsofmagnesiumoxidemgoshapesoninvitroandinvivodegradationbehaviorsofplamgocompositesinlongterm AT chenminfang effectsofmagnesiumoxidemgoshapesoninvitroandinvivodegradationbehaviorsofplamgocompositesinlongterm |