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Interpretation of Drug Interaction Using Systemic and Local Tissue Exposure Changes
Systemic exposure of a drug is generally associated with its pharmacodynamic (PD) effect (e.g., efficacy and toxicity). In this regard, the change in area under the plasma concentration-time curve (AUC) of a drug, representing its systemic exposure, has been mainly considered in evaluation of drug-d...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284846/ https://www.ncbi.nlm.nih.gov/pubmed/32370191 http://dx.doi.org/10.3390/pharmaceutics12050417 |