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Calcium Bioavailability of Opuntia ficus-indica Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss

Osteoporosis is a disease of the skeletal system characterized by low bone mass and bone weakening, which increase the risk of fracture. This disease is associated with menopause because hypoestrogenism induces the maturation and activation of osteoclasts. In addition, a low dietary intake of calciu...

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Autores principales: Quintero-García, Michelle, Gutiérrez-Cortez, Elsa, Rojas-Molina, Alejandra, Mendoza-Ávila, Monsserrat, Del Real, Alicia, Rubio, Efraín, Jiménez-Mendoza, Daniel, Rojas-Molina, Isela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284886/
https://www.ncbi.nlm.nih.gov/pubmed/32429103
http://dx.doi.org/10.3390/nu12051431
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author Quintero-García, Michelle
Gutiérrez-Cortez, Elsa
Rojas-Molina, Alejandra
Mendoza-Ávila, Monsserrat
Del Real, Alicia
Rubio, Efraín
Jiménez-Mendoza, Daniel
Rojas-Molina, Isela
author_facet Quintero-García, Michelle
Gutiérrez-Cortez, Elsa
Rojas-Molina, Alejandra
Mendoza-Ávila, Monsserrat
Del Real, Alicia
Rubio, Efraín
Jiménez-Mendoza, Daniel
Rojas-Molina, Isela
author_sort Quintero-García, Michelle
collection PubMed
description Osteoporosis is a disease of the skeletal system characterized by low bone mass and bone weakening, which increase the risk of fracture. This disease is associated with menopause because hypoestrogenism induces the maturation and activation of osteoclasts. In addition, a low dietary intake of calcium leads to low bone mineral density and postmenopausal osteoporosis. The objectives of this work were to determine calcium bioavailability of Opuntia ficus-indica cladodes at a late maturity stage and to assess its contribution in improving bone health in an ovariectomized rat model. Two-month-old Wistar female rats (n = 35) were used and distributed in seven experimental groups: (i) control group (Crtl), (ii) sham group (SH), (iii) ovariectomized group (OVX), (iv) ovariectomized group supplemented with calcium citrate (CCa), (v) ovariectomized group supplemented with O. ficus-indica powder (NI), (vi) ovariectomized group supplemented with soluble fiber from O. ficus-indica (FS) and (vii) ovariectomized group supplemented with insoluble fiber from O. ficus-indica (FI). Our results showed that calcium in the soluble fiber of O. ficus-indica is bioavailable and contributes to improve the physical, densitometric, biomechanical and microstructural properties of bones in ovariectomized rats. These findings indicated that O. ficus-indica cladodes at a late maturity stage represent a good source of bioavailable calcium and consumption of these cladodes might be beneficial for the prevention of osteoporosis and other bone diseases.
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spelling pubmed-72848862020-06-17 Calcium Bioavailability of Opuntia ficus-indica Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss Quintero-García, Michelle Gutiérrez-Cortez, Elsa Rojas-Molina, Alejandra Mendoza-Ávila, Monsserrat Del Real, Alicia Rubio, Efraín Jiménez-Mendoza, Daniel Rojas-Molina, Isela Nutrients Article Osteoporosis is a disease of the skeletal system characterized by low bone mass and bone weakening, which increase the risk of fracture. This disease is associated with menopause because hypoestrogenism induces the maturation and activation of osteoclasts. In addition, a low dietary intake of calcium leads to low bone mineral density and postmenopausal osteoporosis. The objectives of this work were to determine calcium bioavailability of Opuntia ficus-indica cladodes at a late maturity stage and to assess its contribution in improving bone health in an ovariectomized rat model. Two-month-old Wistar female rats (n = 35) were used and distributed in seven experimental groups: (i) control group (Crtl), (ii) sham group (SH), (iii) ovariectomized group (OVX), (iv) ovariectomized group supplemented with calcium citrate (CCa), (v) ovariectomized group supplemented with O. ficus-indica powder (NI), (vi) ovariectomized group supplemented with soluble fiber from O. ficus-indica (FS) and (vii) ovariectomized group supplemented with insoluble fiber from O. ficus-indica (FI). Our results showed that calcium in the soluble fiber of O. ficus-indica is bioavailable and contributes to improve the physical, densitometric, biomechanical and microstructural properties of bones in ovariectomized rats. These findings indicated that O. ficus-indica cladodes at a late maturity stage represent a good source of bioavailable calcium and consumption of these cladodes might be beneficial for the prevention of osteoporosis and other bone diseases. MDPI 2020-05-15 /pmc/articles/PMC7284886/ /pubmed/32429103 http://dx.doi.org/10.3390/nu12051431 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Quintero-García, Michelle
Gutiérrez-Cortez, Elsa
Rojas-Molina, Alejandra
Mendoza-Ávila, Monsserrat
Del Real, Alicia
Rubio, Efraín
Jiménez-Mendoza, Daniel
Rojas-Molina, Isela
Calcium Bioavailability of Opuntia ficus-indica Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss
title Calcium Bioavailability of Opuntia ficus-indica Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss
title_full Calcium Bioavailability of Opuntia ficus-indica Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss
title_fullStr Calcium Bioavailability of Opuntia ficus-indica Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss
title_full_unstemmed Calcium Bioavailability of Opuntia ficus-indica Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss
title_short Calcium Bioavailability of Opuntia ficus-indica Cladodes in an Ovariectomized Rat Model of Postmenopausal Bone Loss
title_sort calcium bioavailability of opuntia ficus-indica cladodes in an ovariectomized rat model of postmenopausal bone loss
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284886/
https://www.ncbi.nlm.nih.gov/pubmed/32429103
http://dx.doi.org/10.3390/nu12051431
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