A High-Resolution Mass Spectrometry-Based Quantitative Metabolomic Workflow Highlights Defects in 5-Fluorouracil Metabolism in Cancer Cells with Acquired Chemoresistance

Currently, 5-fluorouracil (5-FU)-based combination chemotherapy is the mainstay in the treatment of metastatic colorectal cancer (CRC), which benefits approximately 50% of the patients. However, these tumors inevitably acquire chemoresistance resulting in treatment failure. The molecular mechanisms...

Descripción completa

Detalles Bibliográficos
Autores principales: Shahi, Sanjay, Ang, Ching-Seng, Mathivanan, Suresh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284906/
https://www.ncbi.nlm.nih.gov/pubmed/32384705
http://dx.doi.org/10.3390/biology9050096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284906/
https://www.ncbi.nlm.nih.gov/pubmed/32384705
http://dx.doi.org/10.3390/biology9050096

Ejemplares similares