Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes

The antimicrobial activity of 2-naphtholic and phenolic azo compounds was determined against seven microbial species, Staphylococcus aureus (ATCC 25923), Streptococcus pyrogenes (clinical), and Enterococcus faecalis (ATCC 29212), Salmonella typhi (clinical), Pseudomonas aeruginosa (ATCC 27853), Esch...

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Autores principales: Adu, Joseph Kwasi, Amengor, Cedric Dzidzor Kodjo, Mohammed Ibrahim, Nurudeen, Amaning-Danquah, Cynthia, Owusu Ansah, Charles, Gbadago, Dorcas Dzifa, Sarpong-Agyapong, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284924/
https://www.ncbi.nlm.nih.gov/pubmed/32565831
http://dx.doi.org/10.1155/2020/4850492
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author Adu, Joseph Kwasi
Amengor, Cedric Dzidzor Kodjo
Mohammed Ibrahim, Nurudeen
Amaning-Danquah, Cynthia
Owusu Ansah, Charles
Gbadago, Dorcas Dzifa
Sarpong-Agyapong, Joseph
author_facet Adu, Joseph Kwasi
Amengor, Cedric Dzidzor Kodjo
Mohammed Ibrahim, Nurudeen
Amaning-Danquah, Cynthia
Owusu Ansah, Charles
Gbadago, Dorcas Dzifa
Sarpong-Agyapong, Joseph
author_sort Adu, Joseph Kwasi
collection PubMed
description The antimicrobial activity of 2-naphtholic and phenolic azo compounds was determined against seven microbial species, Staphylococcus aureus (ATCC 25923), Streptococcus pyrogenes (clinical), and Enterococcus faecalis (ATCC 29212), Salmonella typhi (clinical), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 251922), and Candida albicans (ATCC 10231), using the high-throughput spot culture growth inhibition assay (HT-SPOTi). The minimum inhibitory concentrations (MIC) were determined for the active azo dyes. All the azo compounds (A1–B4) were screened for anthelmintic activity against adult Ghanaian earthworms, Hyperiodrilus spp. As part of the systematic investigation for biological activity, all the azo compounds exhibited good antimicrobial activity against the seven human pathogenic microorganisms. All the compounds exhibited anthelminthic activity against adult Ghanaian earthworms, Hyperiodrilus spp.
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spelling pubmed-72849242020-06-18 Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes Adu, Joseph Kwasi Amengor, Cedric Dzidzor Kodjo Mohammed Ibrahim, Nurudeen Amaning-Danquah, Cynthia Owusu Ansah, Charles Gbadago, Dorcas Dzifa Sarpong-Agyapong, Joseph J Trop Med Research Article The antimicrobial activity of 2-naphtholic and phenolic azo compounds was determined against seven microbial species, Staphylococcus aureus (ATCC 25923), Streptococcus pyrogenes (clinical), and Enterococcus faecalis (ATCC 29212), Salmonella typhi (clinical), Pseudomonas aeruginosa (ATCC 27853), Escherichia coli (ATCC 251922), and Candida albicans (ATCC 10231), using the high-throughput spot culture growth inhibition assay (HT-SPOTi). The minimum inhibitory concentrations (MIC) were determined for the active azo dyes. All the azo compounds (A1–B4) were screened for anthelmintic activity against adult Ghanaian earthworms, Hyperiodrilus spp. As part of the systematic investigation for biological activity, all the azo compounds exhibited good antimicrobial activity against the seven human pathogenic microorganisms. All the compounds exhibited anthelminthic activity against adult Ghanaian earthworms, Hyperiodrilus spp. Hindawi 2020-06-01 /pmc/articles/PMC7284924/ /pubmed/32565831 http://dx.doi.org/10.1155/2020/4850492 Text en Copyright © 2020 Joseph Kwasi Adu et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Adu, Joseph Kwasi
Amengor, Cedric Dzidzor Kodjo
Mohammed Ibrahim, Nurudeen
Amaning-Danquah, Cynthia
Owusu Ansah, Charles
Gbadago, Dorcas Dzifa
Sarpong-Agyapong, Joseph
Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title_full Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title_fullStr Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title_full_unstemmed Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title_short Synthesis and In Vitro Antimicrobial and Anthelminthic Evaluation of Naphtholic and Phenolic Azo Dyes
title_sort synthesis and in vitro antimicrobial and anthelminthic evaluation of naphtholic and phenolic azo dyes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284924/
https://www.ncbi.nlm.nih.gov/pubmed/32565831
http://dx.doi.org/10.1155/2020/4850492
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