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Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis

Osteoarthritis (OA) is a chronic inflammatory joint disease that affects millions of elderly people around the world. The conventional treatments for OA consisting of nonsteroidal anti-inflammatory drugs and steroid have negative health consequences, such as gastrointestinal, renal, and cardiac dise...

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Autores principales: Lee, Donghun, Ju, Mi-Kyoung, Kim, Hocheol
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284963/
https://www.ncbi.nlm.nih.gov/pubmed/32438772
http://dx.doi.org/10.3390/nu12051477
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author Lee, Donghun
Ju, Mi-Kyoung
Kim, Hocheol
author_facet Lee, Donghun
Ju, Mi-Kyoung
Kim, Hocheol
author_sort Lee, Donghun
collection PubMed
description Osteoarthritis (OA) is a chronic inflammatory joint disease that affects millions of elderly people around the world. The conventional treatments for OA consisting of nonsteroidal anti-inflammatory drugs and steroid have negative health consequences, such as gastrointestinal, renal, and cardiac diseases. This study has evaluated the Commiphora extract mixture (HT083) on OA progression as an alternative treatment in animal models. The root of P. lactiflora and the gum resin of C. myrrha have been in use as traditional medicines against many health problems including bone disorders since ancient time. The extracts of P. lactiflora root and C. myrrha gum resin were mixed as 3:1 for their optimal effects. Male Sprague-Dawley rats were injected with monosodium iodoacetate (MIA) into the knee joints to induce the symptoms identical to human OA. HT083 substantially prevented the loss of weight-bearing inflicted with MIA in rats. The MIA-induced cartilage erosion as well as the subchondral bone damage in the rats was also reversed. In addition, the increase of serum IL-1β concentration, a crucial pro-inflammatory cytokine involved in OA progression was countered by HT083. Furthermore, HT083 significantly reduced the acetic acid-induced writhing response in mice. In vitro, HT083 has shown potent anti-inflammatory activities by inhibiting the production of NO and suppressing the interleukin -1β, interleukin -6, cyclooxygenase-2, and inducible nitric oxide synthase expression in lipopolysaccharide -stimulated RAW 264.7 cells. Given its potent analgesic and anti-inflammatory activities in MIA rats and acetic acid-induced writhing in mice, HT083 should be further studied in order to explain its mechanism of actions in alleviating OA pain and inflammation.
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spelling pubmed-72849632020-06-17 Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis Lee, Donghun Ju, Mi-Kyoung Kim, Hocheol Nutrients Article Osteoarthritis (OA) is a chronic inflammatory joint disease that affects millions of elderly people around the world. The conventional treatments for OA consisting of nonsteroidal anti-inflammatory drugs and steroid have negative health consequences, such as gastrointestinal, renal, and cardiac diseases. This study has evaluated the Commiphora extract mixture (HT083) on OA progression as an alternative treatment in animal models. The root of P. lactiflora and the gum resin of C. myrrha have been in use as traditional medicines against many health problems including bone disorders since ancient time. The extracts of P. lactiflora root and C. myrrha gum resin were mixed as 3:1 for their optimal effects. Male Sprague-Dawley rats were injected with monosodium iodoacetate (MIA) into the knee joints to induce the symptoms identical to human OA. HT083 substantially prevented the loss of weight-bearing inflicted with MIA in rats. The MIA-induced cartilage erosion as well as the subchondral bone damage in the rats was also reversed. In addition, the increase of serum IL-1β concentration, a crucial pro-inflammatory cytokine involved in OA progression was countered by HT083. Furthermore, HT083 significantly reduced the acetic acid-induced writhing response in mice. In vitro, HT083 has shown potent anti-inflammatory activities by inhibiting the production of NO and suppressing the interleukin -1β, interleukin -6, cyclooxygenase-2, and inducible nitric oxide synthase expression in lipopolysaccharide -stimulated RAW 264.7 cells. Given its potent analgesic and anti-inflammatory activities in MIA rats and acetic acid-induced writhing in mice, HT083 should be further studied in order to explain its mechanism of actions in alleviating OA pain and inflammation. MDPI 2020-05-19 /pmc/articles/PMC7284963/ /pubmed/32438772 http://dx.doi.org/10.3390/nu12051477 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Donghun
Ju, Mi-Kyoung
Kim, Hocheol
Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis
title Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis
title_full Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis
title_fullStr Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis
title_full_unstemmed Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis
title_short Commiphora Extract Mixture Ameliorates Monosodium Iodoacetate-Induced Osteoarthritis
title_sort commiphora extract mixture ameliorates monosodium iodoacetate-induced osteoarthritis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7284963/
https://www.ncbi.nlm.nih.gov/pubmed/32438772
http://dx.doi.org/10.3390/nu12051477
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