Design and Characterization of Phosphatidylcholine-Based Solid Dispersions of Aprepitant for Enhanced Solubility and Dissolution

This study aimed to improve the solubility and dissolution of aprepitant, a drug with poor aqueous solubility, using a phosphatidylcholine (PC)-based solid dispersion system. When fabricating the PC-based solid dispersion, we employed mesoporous microparticles, as an adsorbent, and disintegrants to...

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Detalles Bibliográficos
Autores principales: Yeo, Sooho, An, Jieun, Park, Changhee, Kim, Dohyun, Lee, Jaehwi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285057/
https://www.ncbi.nlm.nih.gov/pubmed/32365589
http://dx.doi.org/10.3390/pharmaceutics12050407

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285057/
https://www.ncbi.nlm.nih.gov/pubmed/32365589
http://dx.doi.org/10.3390/pharmaceutics12050407

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