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Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent
Vitamin C has been known for decades. It is common in everyday use as an element of the diet, supplementation, and a preservative. For years, research has been conducted to precisely determine the mechanism of action of ascorbate in the cell. Available results indicate its multi-directional cellular...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285147/ https://www.ncbi.nlm.nih.gov/pubmed/32455696 http://dx.doi.org/10.3390/nu12051501 |
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author | Kaźmierczak-Barańska, Julia Boguszewska, Karolina Adamus-Grabicka, Angelika Karwowski, Bolesław T. |
author_facet | Kaźmierczak-Barańska, Julia Boguszewska, Karolina Adamus-Grabicka, Angelika Karwowski, Bolesław T. |
author_sort | Kaźmierczak-Barańska, Julia |
collection | PubMed |
description | Vitamin C has been known for decades. It is common in everyday use as an element of the diet, supplementation, and a preservative. For years, research has been conducted to precisely determine the mechanism of action of ascorbate in the cell. Available results indicate its multi-directional cellular effects. Vitamin C, which belongs to antioxidants scavenging free radicals, also has a ‘second face’—as a pro-oxidative factor. However, whether is the latter nature a defect harmful to the cell, or whether a virtue that is a source of benefit? In this review, we discuss the effects of vitamin C treatment in cancer prevention and the role of ascorbate in maintaining redox balance in the central nervous system (CNS). Finally, we discuss the effect of vitamin C supplementation on biomarkers of oxidative DNA damage and review the evidence that vitamin C has radioprotective properties. |
format | Online Article Text |
id | pubmed-7285147 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-72851472020-06-18 Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent Kaźmierczak-Barańska, Julia Boguszewska, Karolina Adamus-Grabicka, Angelika Karwowski, Bolesław T. Nutrients Review Vitamin C has been known for decades. It is common in everyday use as an element of the diet, supplementation, and a preservative. For years, research has been conducted to precisely determine the mechanism of action of ascorbate in the cell. Available results indicate its multi-directional cellular effects. Vitamin C, which belongs to antioxidants scavenging free radicals, also has a ‘second face’—as a pro-oxidative factor. However, whether is the latter nature a defect harmful to the cell, or whether a virtue that is a source of benefit? In this review, we discuss the effects of vitamin C treatment in cancer prevention and the role of ascorbate in maintaining redox balance in the central nervous system (CNS). Finally, we discuss the effect of vitamin C supplementation on biomarkers of oxidative DNA damage and review the evidence that vitamin C has radioprotective properties. MDPI 2020-05-21 /pmc/articles/PMC7285147/ /pubmed/32455696 http://dx.doi.org/10.3390/nu12051501 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Kaźmierczak-Barańska, Julia Boguszewska, Karolina Adamus-Grabicka, Angelika Karwowski, Bolesław T. Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent |
title | Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent |
title_full | Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent |
title_fullStr | Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent |
title_full_unstemmed | Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent |
title_short | Two Faces of Vitamin C—Antioxidative and Pro-Oxidative Agent |
title_sort | two faces of vitamin c—antioxidative and pro-oxidative agent |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7285147/ https://www.ncbi.nlm.nih.gov/pubmed/32455696 http://dx.doi.org/10.3390/nu12051501 |
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